INT145272

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.31
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
liver 2
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.72 Very High Very High Very High
qutenza 14 98.20 Very High Very High Very High
Bile 1 48.32 Quite Low
Disease Link Frequency Relevance Heat
Overdose 3 99.52 Very High Very High Very High
Biliary Liver Cirrhosis 8 98.88 Very High Very High Very High
Disease 1 86.56 High High
Breast Cancer 1 84.56 Quite High
Acute Liver Failure 1 75.00 Quite High
Liver Failure 1 56.80 Quite High
Colon Cancer 2 56.56 Quite High
Injury 2 49.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Positive_regulation (increases) of Transcription (levels) of multi-drug resistance associated protein 1 associated with qutenza
1) Confidence 0.49 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Positive_regulation (increases) of Transcription (levels) of MRP1 associated with qutenza
2) Confidence 0.49 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
Compared with normal liver specimens, MRP1 and MRP4 mRNA levels were elevated after APAP overdose and in PBC.
Positive_regulation (elevated) of Transcription (levels) of MRP1 in liver associated with biliary liver cirrhosis, paracetamol and overdose
3) Confidence 0.45 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.20 Pain Relevance 0.54

General Comments

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