INT145273

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.72
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCG2) ATPase activity (ABCG2) plasma membrane (ABCG2)
transmembrane transport (ABCG2)
Anatomy Link Frequency
livers 2
intestine 1
ABCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High
Bioavailability 3 71.56 Quite High
Bile 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 16 100.00 Very High Very High Very High
Overdose 6 100.00 Very High Very High Very High
Breast Cancer 2 100.00 Very High Very High Very High
Acute Liver Failure 2 75.00 Quite High
Disease 2 62.16 Quite High
Liver Failure 2 32.40 Quite Low
Injury 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of mRNAs of efflux transporters analyzed by real-time RT-PCR indicated that mRNA expression levels of MDR1, MRP2, and BCRP in monkey intestine were significantly higher than those in human intestine.
Transcription (expression) of BCRP in intestine
1) Confidence 0.69 Published 2008 Journal Mol. Pharm. Section Abstract Doc Link 18247527 Disease Relevance 0 Pain Relevance 0.38
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Spec (determined) Transcription (determined) of BCRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
2) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.90 Pain Relevance 0.44
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (expression) of BCRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
3) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.82 Pain Relevance 0.44

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