INT145274

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.46
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCG2) ATPase activity (ABCG2) plasma membrane (ABCG2)
transmembrane transport (ABCG2)
Anatomy Link Frequency
livers 1
ABCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 10 99.24 Very High Very High Very High
Paracetamol 14 99.12 Very High Very High Very High
Analgesic 1 94.92 High High
Inflammation 1 94.16 High High
Perioperative pain 1 92.24 High High
rheumatoid arthritis 1 91.44 High High
tetrodotoxin 12 90.72 High High
Cancer pain 1 90.08 High High
Versed 2 84.52 Quite High
Morphine 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 16 99.92 Very High Very High Very High
Disease 3 99.64 Very High Very High Very High
Breast Cancer 4 99.58 Very High Very High Very High
Overdose 6 99.48 Very High Very High Very High
INFLAMMATION 1 94.16 High High
Post Operative Pain 1 92.24 High High
Rheumatoid Arthritis 1 91.44 High High
Cancer Pain 1 90.08 High High
Obesity 19 77.40 Quite High
Acute Liver Failure 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Positive_regulation (increased) of BCRP associated with biliary liver cirrhosis and disease
1) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.35 Pain Relevance 0.57
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.
Positive_regulation (stimulation) of ABCG2 associated with breast cancer and diclofenac
2) Confidence 0.49 Published 2009 Journal Drug Metab. Dispos. Section Title Doc Link 18845662 Disease Relevance 0.54 Pain Relevance 0.75
ABCB1, ABCG2 and transferrin receptor proteins were detected and functional activity of ABCB1, ABCG2 and the ABCC family was quantified in efflux experiments.
Positive_regulation (activity) of ABCG2
3) Confidence 0.48 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.12
RT-PCR analysis demonstrated that the mRNA levels encoding for ABCG2, nestin, Tuj1, MAP2, NFL, NFM, NSE, GAP43, SNAP25, GFAP, and CNPase were also highly increased in NI-hADSCs.
Positive_regulation (increased) of ABCG2
4) Confidence 0.36 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.28 Pain Relevance 0.24
Up-regulation of MRP5, MDR1, and BCRP mRNA occurred in PBC livers.
Positive_regulation (Up-regulation) of BCRP mRNA in livers associated with biliary liver cirrhosis
5) Confidence 0.10 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.28 Pain Relevance 0.57

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox