INT145279

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 16.58
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
striatum 1
cortex 1
cerebellum 1
ventral 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 28 97.96 Very High Very High Very High
ischemia 19 96.16 Very High Very High Very High
Neuropeptide 1 94.34 High High
spinal inflammation 31 93.16 High High
fibrosis 208 93.04 High High
Arthritis 34 92.84 High High
rheumatoid arthritis 54 92.64 High High
withdrawal 8 81.52 Quite High
Raphe 3 79.28 Quite High
Pain 4 76.96 Quite High
Disease Link Frequency Relevance Heat
Thrombocytopenia 15 99.96 Very High Very High Very High
Pulmonary Disease 192 99.76 Very High Very High Very High
Hemorrhage 60 99.60 Very High Very High Very High
Disease 107 99.12 Very High Very High Very High
Anaemia 476 98.98 Very High Very High Very High
Heart Disease 11 98.44 Very High Very High Very High
Cancer 353 98.16 Very High Very High Very High
Targeted Disruption 444 97.80 Very High Very High Very High
Coronary Artery Disease 7 96.16 Very High Very High Very High
Death 23 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HB (lox/lox) mice showed the same expression patterns for HB-EGF mRNA and protein in various regions of the brain (hippocampus, prefrontal cortex, cerebellum, and striatum) when compared with wild-type C57BL/6J mice (data not shown).
Regulation (patterns) of HB-EGF in striatum associated with hippocampus
1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.80 Pain Relevance 0.12
To investigate the roles of HB-EGF in psychomotor behavior, we performed a comprehensive behavioral analysis of ventral forebrain-specific HB-EGF KO mice.
Spec (investigate) Regulation (roles) of HB-EGF in ventral associated with targeted disruption
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.52 Pain Relevance 0.12
Hemoglobin concentrations were calculated from a known Hb control, which was run in parallel.


Regulation (control) of Hb
3) Confidence 0.23 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 0.27 Pain Relevance 0.04
Increase in MCV values displaying reciprocal relationship with RBC, PCV, and Hb values in lead-treated mice were also recorded.
Regulation (values) of Hb
4) Confidence 0.22 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964740 Disease Relevance 0.17 Pain Relevance 0
Significant increase and decrease in RBC and WBC were recorded, respectively, but no changes in levels of PCV and Hb.
Neg (no) Regulation (changes) of Hb
5) Confidence 0.18 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17628367 Disease Relevance 0.14 Pain Relevance 0
The changes in the Hb composition could be seen not only in the complex formation but also in both Hb monomers.
Regulation (changes) of Hb
6) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.79 Pain Relevance 0.21
Again, the correlation between treatment-related changes in Hb level and QoL effects was demonstrated (p < 0.05).


Regulation (changes) of Hb
7) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.58 Pain Relevance 0.05
The efficacy of ESA treatment in increasing Hb levels was shown in a randomized, placebo-controlled study in nonmyeloid malignancies, where the responses rates were 67% vs 27% in the epoetin beta and placebo groups, respectively (p < 0.0001) (Osterborg et al 2002).
Regulation (efficacy) of Hb
8) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.49 Pain Relevance 0
In recent years, the importance of the Hb level for physical capacity and quality of life (QoL) has been extensively investigated, and as a result the use of erythropoiesis-stimulating agents (ESA) in cancer patients has increased.


Spec (investigated) Regulation (importance) of Hb associated with cancer
9) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.34 Pain Relevance 0.03
However, randomized controlled trials targeting different hemoglobin (Hb) levels in hemodialysis patients with cardiac disease show conflicting results.
Regulation (targeting) of Hb associated with heart disease
10) Confidence 0.14 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.87 Pain Relevance 0
The effect on Hb was independent of the frequency of administration and responses were sustained until the end of the study (Provenzano et al 2004).
Regulation (effect) of Hb
11) Confidence 0.14 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.15 Pain Relevance 0
Hedenus and colleagues (2003) found a statistically significant relationship (p < 0.001) between change in Hb and change in FACT-An scores and also showed that patients with a lower base-line FACT-An score reported the largest improvements.
Regulation (change) of Hb
12) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.57 Pain Relevance 0
HB (lox/lox) mice showed the same expression patterns for HB-EGF mRNA and protein in various regions of the brain (hippocampus, prefrontal cortex, cerebellum, and striatum) when compared with wild-type C57BL/6J mice (data not shown).
Regulation (patterns) of HB-EGF in cortex associated with hippocampus
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.80 Pain Relevance 0.12
HB (lox/lox) mice showed the same expression patterns for HB-EGF mRNA and protein in various regions of the brain (hippocampus, prefrontal cortex, cerebellum, and striatum) when compared with wild-type C57BL/6J mice (data not shown).
Regulation (patterns) of HB-EGF in cerebellum associated with hippocampus
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.80 Pain Relevance 0.12
It was not possible to determine whether Hb levels vary between the controls and the disease states since the major difference i.e. the changes in the Hb?
Spec (whether) Regulation (changes) of Hb associated with disease
15) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.45 Pain Relevance 0.10
No corresponding changes in the Hb?
Neg (No) Regulation (changes) of Hb
16) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.12 Pain Relevance 0.27
The Hb expresses receptors for neuropeptides associated with SCN efferents (Hernando et al., 2001; Cheng et al., 2006) as well as melatonin binding sites (Weaver et al., 1989), and retinal efferents arising from mRGCs innervate the LHb region (Hattar et al., 2006), indicating that photic and SCN-controlled output signals can regulate Hb cellular activity.
Regulation (regulate) of Hb associated with neuropeptide
17) Confidence 0.09 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0.26 Pain Relevance 0.23
to target tissues by regulating hemoglobin (Hb) function and
Regulation (regulating) of Hb
18) Confidence 0.06 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.35 Pain Relevance 0.14
GLM treatment significantly improved anemia compared with placebo.40 Associations between the change in hemoglobin (Hb) levels and that in the SF-36 vitality scale or that in physical function, as measured using the HAQ disability index, were assessed through week 24.
Regulation (change) of Hb associated with anaemia
19) Confidence 0.03 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 2.04 Pain Relevance 0.77
No significant results were noted in thrombocytopenia, change in Hb/ Hct, HACA.
Regulation (change) of Hb associated with thrombocytopenia
20) Confidence 0.02 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615343 Disease Relevance 0.90 Pain Relevance 0.03

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