INT145281

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 89
Total Number 90
Disease Relevance 63.22
Pain Relevance 11.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sputum 6
lung 6
epithelium 3
central nervous system 2
striatum 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 3728 99.52 Very High Very High Very High
Action potential 48 99.44 Very High Very High Very High
Neuropeptide 8 99.40 Very High Very High Very High
Hippocampus 91 97.96 Very High Very High Very High
Central nervous system 50 94.64 High High
COX2 1 91.88 High High
Pain 14 89.88 High High
alcohol 58 88.56 High High
Inflammation 349 86.40 High High
nMDA receptor 52 85.88 High High
Disease Link Frequency Relevance Heat
Pulmonary Disease 3456 99.98 Very High Very High Very High
Targeted Disruption 1447 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 144 99.56 Very High Very High Very High
Mental Disorders 52 99.56 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 3726 99.52 Very High Very High Very High
Anaemia 538 99.50 Very High Very High Very High
Disease 937 99.40 Very High Very High Very High
Cv Unclassified Under Development 33 99.16 Very High Very High Very High
Schizophrenia 177 99.00 Very High Very High Very High
Stress 413 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the prefrontal cortex, the expression of Hb-egf mRNA and protein were found to be considerably reduced in KO mice (Fig. 1d).
Gene_expression (expression) of Hb-egf in prefrontal associated with targeted disruption
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.87 Pain Relevance 0.13
HB (lox/lox) mice showed the same expression patterns for HB-EGF mRNA and protein in various regions of the brain (hippocampus, prefrontal cortex, cerebellum, and striatum) when compared with wild-type C57BL/6J mice (data not shown).
Gene_expression (expression) of HB-EGF in striatum associated with hippocampus
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.80 Pain Relevance 0.12
and HB-EGF) are expressed at much higher levels than EGF itself [11], HB-EGF itself could be serving as a major physiologic ligand for EGF receptor within the central nervous system.
Gene_expression (expressed) of HB-EGF in central nervous system associated with central nervous system
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.45 Pain Relevance 0.16
Similarly, HB-EGF protein was undetectable beyond the background level in the cell layer of CA1, CA3, and dentate gyrus (DG) of KO mice hippocampus (Fig. 1g).
Gene_expression (undetectable) of HB-EGF in hippocampus associated with targeted disruption and hippocampus
4) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.80 Pain Relevance 0.16
DIG-labeled cRNA probes corresponding to Hb-egf (NM_010415) nucleotide positions 546 to 665 were synthesized, in situ hybridization analysis was performed, as previously reported [52], and frozen sections (10 ┬Ám thick) were stained with cresyl violet (Sigma, St.
Gene_expression (synthesized) of Hb-egf
5) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0 Pain Relevance 0.06
For a further examination of the expression of Hb-egf mRNA and its protein in HB-EGF KO and control mice, we performed in situ hybridization analysis and immunohistrochemical analysis respectively (Fig. 1d).
Gene_expression (expression) of Hb-egf associated with targeted disruption
6) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.73 Pain Relevance 0.13
Generation of HB-EGF KO mice using a gene targeting Cre-loxP and PCR
Gene_expression (Generation) of HB-EGF associated with targeted disruption
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.50 Pain Relevance 0.04
Generation of HB-EGF KO mice
Gene_expression (Generation) of HB-EGF associated with targeted disruption
8) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.89 Pain Relevance 0.08
and HB-EGF) are expressed at much higher levels than EGF itself [11], it is possible that HB-EGF serves as a major physiologic ligand for the EGF receptor within the central nervous system.
Gene_expression (expressed) of HB-EGF in central nervous system associated with central nervous system
9) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.84 Pain Relevance 0.22
In contrast, no significant differences were observed in the expression of NR2A and total NR2B proteins between controls and HB-EGF KO mice (P>0.05 vs. control mice) (Fig. 4k and l).


Gene_expression (expression) of HB-EGF associated with targeted disruption
10) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.76 Pain Relevance 0.04
Despite the decreased expression HB-EGF, the overall development of HB-EGF KO mice appeared to be normal and there were no significant differences in the body weight in the adult KO or control mice.
Gene_expression (expression) of HB-EGF in body associated with targeted disruption and body weight
11) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.19 Pain Relevance 0.05
Before any intervention, HbT concentration was measured as approximately 70 ?
Gene_expression (concentration) of HbT
12) Confidence 0.44 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0.15 Pain Relevance 0
A prospective, randomized, placebo-controlled study with over 300 myeloma and lymphoma patients showed major improvements in FACT-An as well as Linear Analogue Scales (LASA) for the patients who had a Hb improvement from ESA treatment (Littlewood et al 2001), and this univariate analysis was later supported by a multiple linear regression analysis of the same material, accounting for disease progression and other possible confounding factors (Fallowfield et al 2002).
Gene_expression (improvement) of Hb associated with lymphatic system cancer and disease progression
13) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.78 Pain Relevance 0
The strong correlation between prognosis and Hb levels at diagnosis makes it tempting to hypothesise that treatment of anemia would improve survival.
Gene_expression (prognosis) of Hb associated with anaemia
14) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.94 Pain Relevance 0
The efficacy of ESA treatment in increasing Hb levels was shown in a randomized, placebo-controlled study in nonmyeloid malignancies, where the responses rates were 67% vs 27% in the epoetin beta and placebo groups, respectively (p < 0.0001) (Osterborg et al 2002).
Gene_expression (levels) of Hb
15) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.47 Pain Relevance 0
Although there is a lack of consensus surrounding the desired upper limit of the Hb level due to a lack of evidence, the EBPG suggest limiting Hb levels to <14 g/dL in hemodialysis patients and to <12 g/dL in patients with severe cardiovascular disease and in patients with diabetes and peripheral vascular disease.
Gene_expression (levels) of Hb in upper associated with diabetes mellitus, cardiovascular disease and increased venous pressure under development
16) Confidence 0.34 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 1.42 Pain Relevance 0.04
The main concerns with higher Hb targets include the risk of hypertension and vascular thrombosis.
Gene_expression (targets) of Hb associated with cv unclassified under development and thrombosis
17) Confidence 0.34 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 1.21 Pain Relevance 0.03
There is emerging evidence to suggest that the adverse effects of anemia are not only related to Hb levels but also to the low levels of EPO.
Gene_expression (levels) of Hb associated with anaemia
18) Confidence 0.34 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 1.00 Pain Relevance 0.03
However, treatment may be started even at a Hb ?
Gene_expression (started) of Hb
19) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.55 Pain Relevance 0
It is not known whether these changes impact on the expression Hb in the COPD lung, although some kind of association is not impossible.
Gene_expression (expression) of Hb in lung associated with pulmonary disease
20) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.12 Pain Relevance 0.17

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