INT145297

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 5.52
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) intracellular (Jak3) kinase activity (Jak3)
cytoplasm (Jak3)
Anatomy Link Frequency
mast cells 2
Jak3 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 18 98.96 Very High Very High Very High
Inflammation 14 97.04 Very High Very High Very High
Inflammatory mediators 1 94.48 High High
Hyperalgesia 2 92.64 High High
Pain 2 91.96 High High
pain pelvic 4 78.88 Quite High
Central nervous system 3 74.88 Quite High
Analgesic 2 64.20 Quite High
Neurobehavioral 1 58.28 Quite High
Dismenorea 4 57.96 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 20 98.96 Very High Very High Very High
Breast Cancer 1 97.08 Very High Very High Very High
INFLAMMATION 15 97.04 Very High Very High Very High
Adhesions 4 95.28 Very High Very High Very High
Nociception 4 94.28 High High
Hyperalgesia 2 92.64 High High
Pain 2 91.96 High High
Cancer 21 88.40 High High
Hypersensitivity 2 81.20 Quite High
Reprotox - General 3 6 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high-affinity IgE receptor-mediated mast cell inflammatory sequelae.
Positive_regulation (required) of Janus kinase 3 in mast cells associated with inflammation
1) Confidence 0.50 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.37 Pain Relevance 1.00
The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high-affinity IgE receptor-mediated mast cell inflammatory sequelae.
Positive_regulation (required) of JAK3 in mast cells associated with inflammation
2) Confidence 0.50 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.36 Pain Relevance 0.99
It appears that activation of JAK3, EGFR, Src kinase, and MAP kinase signaling cascades may underlie these effects (Eum et al. 2004, 2006).
Positive_regulation (activation) of JAK3
3) Confidence 0.22 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.78 Pain Relevance 0.15

General Comments

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