INT145298

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.69
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) intracellular (Jak3) kinase activity (Jak3)
cytoplasm (Jak3)
Anatomy Link Frequency
mast cells 3
platelets 1
thymocytes 1
Jak3 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 18 98.96 Very High Very High Very High
Inflammation 90 95.84 Very High Very High Very High
cytokine 50 95.60 Very High Very High Very High
cINOD 1 93.28 High High
Hyperalgesia 2 92.64 High High
Pain 2 91.96 High High
Arthritis 81 79.04 Quite High
pain pelvic 4 78.88 Quite High
methotrexate 2 71.76 Quite High
rheumatoid arthritis 39 65.76 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 20 98.96 Very High Very High Very High
INFLAMMATION 90 95.84 Very High Very High Very High
Nociception 4 94.28 High High
Hyperalgesia 2 92.64 High High
Pain 2 91.96 High High
Apoptosis 9 90.60 High High
Hypersensitivity 23 87.32 High High
Arthritis 84 79.04 Quite High
Reprotox - General 3 6 78.88 Quite High
Adverse Drug Reaction 1 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high-affinity IgE receptor-mediated mast cell inflammatory sequelae.
Gene_expression (expressed) of Janus kinase 3 in mast cells associated with inflammation
1) Confidence 0.78 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.35 Pain Relevance 1.00
The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high-affinity IgE receptor-mediated mast cell inflammatory sequelae.
Gene_expression (expressed) of JAK3 in mast cells associated with inflammation
2) Confidence 0.78 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.34 Pain Relevance 0.99
Interestingly, JAK3 expression has been shown to decrease in the synovial tissue biopsies from active rheumatoid arthritics receiving and responding to DMARD therapy [8].
Gene_expression (expression) of JAK3
3) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.88 Pain Relevance 0.42
JAK3 is expressed at high levels in NK cells and normally in thymocytes, platelets, mast cells, and inducible T and B cells.
Gene_expression (expressed) of JAK3 in platelets
4) Confidence 0.31 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.61 Pain Relevance 0.19
change in the expression of JAK3, DFFB, NSEP1, and TERF1 genes [21].
Gene_expression (expression) of JAK3
5) Confidence 0.22 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.29 Pain Relevance 0.09
JAK3 is expressed at high levels in NK cells and normally in thymocytes, platelets, mast cells, and inducible T and B cells.
Gene_expression (expressed) of JAK3 in mast cells
6) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.61 Pain Relevance 0.19
JAK3 is expressed at high levels in NK cells and normally in thymocytes, platelets, mast cells, and inducible T and B cells.
Gene_expression (expressed) of JAK3 in thymocytes
7) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.61 Pain Relevance 0.19

General Comments

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