INT145300

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bmp2) growth (Bmp2) extracellular region (Bmp2)
embryo development (Bmp2) protein complex (Bmp2) cytoplasm (Bmp2)
Anatomy Link Frequency
osteoblast 2
SFs 2
Bmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 3 18.20 Low Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Myofascial pain syndrome 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
cOX1 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 41 99.32 Very High Very High Very High
Lifespan 9 77.16 Quite High
Temporomandibular Joint Syndrome 1 72.76 Quite High
Apoptosis 15 71.36 Quite High
Hypercalcemia 3 31.76 Quite Low
Fracture Healing 3 23.36 Low Low
Postmenopausal Osteoporosis 2 23.00 Low Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Bone Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is still unclear how bisphosphonates could stimulate directly bone formation, even if many metabolic pathways have been suggested: the stimulation of b-FGF [10] and of Bone Morphogenetic Protein -2 (BMP-2) [17], the upregulation of a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) [18], the influence on OPG/RANKL system [2].
Positive_regulation (upregulation) of Positive_regulation (stimulation) of Bone Morphogenetic Protein -2 in osteoblast associated with osteoporosis
1) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.95 Pain Relevance 0
Exposure of SFs to HP for 12h resulted in significant up-regulation of BMP-2 by 46, 54, and 66% at 30, 60, and 90kPa, respectively, whilst TGF-beta increased by 11, 19, and 28% at 30, 60, and 90kPa, respectively.
Positive_regulation (up) of Positive_regulation (regulation) of BMP-2 in SFs
2) Confidence 0.33 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17631391 Disease Relevance 0.07 Pain Relevance 0

General Comments

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