INT145302

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Sox9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 52.24 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Myofascial pain syndrome 1 5.00 Very Low Very Low Very Low
Snapping jaw 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nerve Sheath Neoplasms 13 99.80 Very High Very High Very High
Malignant Neoplastic Disease 9 97.86 Very High Very High Very High
Microsatellite Instability 3 97.52 Very High Very High Very High
Neurofibroma 9 91.44 High High
Cancer 17 90.80 High High
Temporomandibular Joint Syndrome 1 65.60 Quite High
Watson Syndrome 6 50.00 Quite Low
Metastasis 8 46.80 Quite Low
Plexiform Neurofibroma 7 28.60 Quite Low
Disease 4 28.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HP also induced the increase of SOX-9 by 72% at 30kPa and 83% at 60kPa, but only 54% at 90kPa.
Positive_regulation (increase) of SOX-9
1) Confidence 0.48 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17631391 Disease Relevance 0.07 Pain Relevance 0
Gene expression profiling in NF1-associated benign and malignant tumours identified relatively widespread deregulation of genes in developing schawnn cells and in particular, the SOX9 gene seems to be essential for MPNST cell survival [18].
Positive_regulation (essential) of SOX9 associated with nerve sheath neoplasms and malignant neoplastic disease
2) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2924852 Disease Relevance 1.36 Pain Relevance 0.03

General Comments

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