INT145305

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 8.65
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bmp2) growth (Bmp2) extracellular region (Bmp2)
embryo development (Bmp2) protein complex (Bmp2) cytoplasm (Bmp2)
Anatomy Link Frequency
osteoblast 6
SFs 2
stromal cells 1
tendon 1
Bmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 98.24 Very High Very High Very High
Pain 6 88.84 High High
cOX1 6 54.64 Quite High
potassium channel 1 54.48 Quite High
spinal inflammation 2 50.00 Quite Low
Osteoarthritis 13 37.96 Quite Low
Paracetamol 6 37.36 Quite Low
analgesia 6 34.48 Quite Low
cytokine 6 24.92 Low Low
COX2 18 18.20 Low Low
Disease Link Frequency Relevance Heat
Osteoporosis 259 100.00 Very High Very High Very High
Targeted Disruption 8 99.82 Very High Very High Very High
Calcification 117 99.74 Very High Very High Very High
Injury 62 98.80 Very High Very High Very High
Pulmonary Disease 1 98.80 Very High Very High Very High
INFLAMMATION 20 98.24 Very High Very High Very High
Pancreatitis 1 97.56 Very High Very High Very High
Tendinopathy 52 94.56 High High
Nociception 1 90.92 High High
Pain 6 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also increase in BMP-2 mRNA at week 2 and week 4 in both injury models though it was statistically significant only at week 2 for the collagenase-induced calcific tendinopathy group.
Positive_regulation (increase) of BMP-2 mRNA associated with calcification, injury and tendinopathy
1) Confidence 0.69 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 1.02 Pain Relevance 0
Giuliani et al. [10] reported that the anabolic effect of BPs was associated with the stimulation of b-FGF, while Mundy et al. demonstrated that the anabolic effect of statins, which influence the mevalonate pathway as BPs, was due to their stimulation of Bone Morphogenetic Protein-2 (BMP-2) [17]; BMP-2 gene expression was also upregulated during osteoblast maturation after BP treatment [18].
Positive_regulation (stimulation) of BMP-2 in osteoblast associated with osteoporosis
2) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.52 Pain Relevance 0
Exposure of SFs to HP for 12h resulted in significant up-regulation of BMP-2 by 46, 54, and 66% at 30, 60, and 90kPa, respectively, whilst TGF-beta increased by 11, 19, and 28% at 30, 60, and 90kPa, respectively.
Positive_regulation (up) of BMP-2 in SFs
3) Confidence 0.49 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17631391 Disease Relevance 0.07 Pain Relevance 0
No significant increase in BMP-2 mRNA was observed in C1/3 group at all time points.


Neg (No) Positive_regulation (increase) of BMP-2 mRNA
4) Confidence 0.47 Published 2009 Journal J Orthop Surg Res Section Abstract Doc Link PMC2725034 Disease Relevance 0.66 Pain Relevance 0
There was increased sensitivity of tendon progenitor cells from biglycan- and fibromodulin- knockout mice to BMP-2 stimulation with increased phosphorylation of Smad1, Smad5 and Smad8 as well as more abundant nuclear localization of phosphorylated Smad1 than those of wild type cells [12].
Positive_regulation (stimulation) of BMP-2 in tendon associated with targeted disruption
5) Confidence 0.47 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.41 Pain Relevance 0
There was significant increase in BMP-2 mRNA compared to that in the contralateral side at week 2 and the level became insignificantly different at week 12 in CI group.
Positive_regulation (increase) of BMP-2 mRNA
6) Confidence 0.47 Published 2009 Journal J Orthop Surg Res Section Abstract Doc Link PMC2725034 Disease Relevance 0.81 Pain Relevance 0
MATERIALS AND METHODS: A case review was made of 14 patients who were selected from a larger group having received BMP-2 in different categories of mandibular defects.
Positive_regulation (received) of BMP-2
7) Confidence 0.44 Published 2008 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 18355584 Disease Relevance 0 Pain Relevance 0
Giuliani et al. [10] reported that the anabolic effect of BPs was associated with the stimulation of b-FGF, while Mundy et al. demonstrated that the anabolic effect of statins, which influence the mevalonate pathway as BPs, was due to their stimulation of Bone Morphogenetic Protein-2 (BMP-2) [17]; BMP-2 gene expression was also upregulated during osteoblast maturation after BP treatment [18].
Positive_regulation (stimulation) of Bone Morphogenetic Protein-2 in osteoblast associated with osteoporosis
8) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.52 Pain Relevance 0
Moreover, LXN gene was upregulated in BMP-2-treated C2C12 cells, suggesting a role in osteoblast differentiation [25].


Positive_regulation (upregulated) of BMP-2 in osteoblast associated with osteoporosis
9) Confidence 0.34 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.90 Pain Relevance 0.21
Von Knoch et al. showed that a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) were up regulated and significantly increased in bone marrow stromal cells after BP treatment [11].
Positive_regulation (increased) of BMP-2 in stromal cells associated with osteoporosis
10) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.52 Pain Relevance 0.03
It is still unclear how bisphosphonates could stimulate directly bone formation, even if many metabolic pathways have been suggested: the stimulation of b-FGF [10] and of Bone Morphogenetic Protein -2 (BMP-2) [17], the upregulation of a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) [18], the influence on OPG/RANKL system [2].
Positive_regulation (stimulation) of Bone Morphogenetic Protein -2 in osteoblast associated with osteoporosis
11) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.94 Pain Relevance 0
It is still unclear how bisphosphonates could stimulate directly bone formation, even if many metabolic pathways have been suggested: the stimulation of b-FGF [10] and of Bone Morphogenetic Protein -2 (BMP-2) [17], the upregulation of a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) [18], the influence on OPG/RANKL system [2].
Positive_regulation (upregulation) of BMP-2 in osteoblast associated with osteoporosis
12) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.94 Pain Relevance 0
It is still unclear how bisphosphonates could stimulate directly bone formation, even if many metabolic pathways have been suggested: the stimulation of b-FGF [10] and of Bone Morphogenetic Protein -2 (BMP-2) [17], the upregulation of a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) [18], the influence on OPG/RANKL system [2].
Positive_regulation (stimulation) of BMP-2 in osteoblast associated with osteoporosis
13) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.95 Pain Relevance 0
Exposure of SFs to HP for 12h resulted in significant up-regulation of BMP-2 by 46, 54, and 66% at 30, 60, and 90kPa, respectively, whilst TGF-beta increased by 11, 19, and 28% at 30, 60, and 90kPa, respectively.
Positive_regulation (regulation) of BMP-2 in SFs
14) Confidence 0.33 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17631391 Disease Relevance 0.07 Pain Relevance 0
RESULTS: At baseline, both AS and RA patients demonstrated significantly elevated serum BMP-2 and BMP-7 levels compared with healthy controls (p<0.05).
Positive_regulation (elevated) of BMP-2
15) Confidence 0.26 Published 2008 Journal Scand. J. Rheumatol. Section Body Doc Link 18465455 Disease Relevance 0.14 Pain Relevance 0
Rat BMP-4 mRNA expression was weak in the BMP-2 and in the BMP-7 single-gene transfer groups.


Positive_regulation (weak) of BMP-2
16) Confidence 0.25 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.07 Pain Relevance 0
In addition, calcification was further advanced in these pCAGGS-BMP-2 and pCAGGS-BMP-7-treated specimens than in the pCAGGS-BMP-2-treated specimens, as revealed by von Kossa stain (Fig. 5D).
Positive_regulation (advanced) of pCAGGS-BMP-2 associated with calcification
17) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0

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