INT145306

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.47
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Anatomy Link Frequency
SFs 3
intervertebral space 2
chondrocytes 1
Sox9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 4 98.88 Very High Very High Very High
Osteoarthritis 4 95.92 Very High Very High Very High
Myofascial pain syndrome 4 94.08 High High
Inflammation 1 85.52 High High
Chronic low back pain 1 61.92 Quite High
metalloproteinase 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 4 98.88 Very High Very High Very High
Intervertebral Disk Degeneration 28 98.20 Very High Very High Very High
Osteoarthritis 4 95.92 Very High Very High Very High
Rheumatic Diseases 4 95.16 Very High Very High Very High
Temporomandibular Joint Disorders 4 94.08 High High
Arthritis 4 93.80 High High
Disease 7 93.40 High High
INFLAMMATION 1 85.52 High High
Osteoporosis 42 81.56 Quite High
Low Back Pain 1 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sox9 was expressed in chondrocytes in non-deformed vertebral bodies (Figure 7E) and in chordoblasts.
Gene_expression (expressed) of Sox9 in chondrocytes
1) Confidence 0.54 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.19 Pain Relevance 0
However, ISH revealed that whereas sox9 and col2a was present in chordoblasts from the non-deformed stage, runx2 and col1a was only detected in fused samples, when intervertebral space was severely narrowed.
Gene_expression (present) of sox9 in intervertebral space
2) Confidence 0.54 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.18 Pain Relevance 0
Production of TGF-beta, BMP-2 and SOX-9 was examined by immunocytochemical assay and western blot.
Spec (examined) Gene_expression (Production) of SOX-9
3) Confidence 0.54 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17631391 Disease Relevance 0.09 Pain Relevance 0
Effects of hydrostatic pressure on cytoskeleton and BMP-2, TGF-beta, SOX-9 production in rat temporomandibular synovial fibroblasts.
Gene_expression (production) of SOX-9 in fibroblasts
4) Confidence 0.54 Published 2008 Journal Osteoarthr. Cartil. Section Title Doc Link 17631391 Disease Relevance 0.46 Pain Relevance 0.22
In intermediate and fused samples, strong signals of sox9 were detected in intervertebral space (Figure 7F).
Gene_expression (detected) of sox9 in intervertebral space
5) Confidence 0.47 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.08 Pain Relevance 0
This study examines the effects of hydrostatic pressure (HP) on cytoskeleton and protein production of bone morphogenetic protein-2 (BMP-2), transforming growth factor-beta (TGF-beta) and the SRY HMG box related gene 9 (SOX-9) in synovial fibroblasts (SFs) of rat temporomandibular joint (TMJ).
Gene_expression (production) of SOX-9 in SFs associated with snapping jaw
6) Confidence 0.42 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 17631391 Disease Relevance 0.57 Pain Relevance 0.24
This study examines the effects of hydrostatic pressure (HP) on cytoskeleton and protein production of bone morphogenetic protein-2 (BMP-2), transforming growth factor-beta (TGF-beta) and the SRY HMG box related gene 9 (SOX-9) in synovial fibroblasts (SFs) of rat temporomandibular joint (TMJ).
Gene_expression (production) of SRY HMG box related gene 9 in SFs associated with snapping jaw
7) Confidence 0.42 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 17631391 Disease Relevance 0.57 Pain Relevance 0.24
After 3 weeks these cells had differentiated into cells expressing chondrocytic phenotype (Collagen II and Sox-9).
Gene_expression (expressing) of Sox-9
8) Confidence 0.39 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18853431 Disease Relevance 0.34 Pain Relevance 0.10

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