INT145312

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 12.71
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
plasma 2
macrophages 1
cartilage 1
osteoclast 1
intervertebral disc 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 33 100.00 Very High Very High Very High
Inflammation 155 97.88 Very High Very High Very High
backache 2 91.72 High High
metalloproteinase 2 89.04 High High
rheumatoid arthritis 53 86.64 High High
Arthritis 13 80.52 Quite High
psoriasis 4 69.84 Quite High
tolerance 22 58.08 Quite High
Inflammatory marker 9 50.00 Quite Low
cINOD 2 28.72 Quite Low
Disease Link Frequency Relevance Heat
Obesity 111 99.86 Very High Very High Very High
Diabetes Mellitus 259 99.64 Very High Very High Very High
Atherosclerotic Plaque 6 99.60 Very High Very High Very High
Metastasis 6 99.12 Very High Very High Very High
Hypercalcemia 1 98.14 Very High Very High Very High
INFLAMMATION 160 97.88 Very High Very High Very High
Intervertebral Disk Degeneration 4 97.72 Very High Very High Very High
Atherosclerosis 57 97.52 Very High Very High Very High
Gastrointestinal Neoplasms 2 96.64 Very High Very High Very High
Calcification 279 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, IL-4 inhibits bone resorption through an effect on both osteoclast activity and survival [75] and reduces the spontaneous secretion of proinflammatory cytokines and Ig in ex vivo cultured pieces from the rheumatoid synovial membrane [76].
Localization (secretion) of synovial in osteoclast associated with hypercalcemia and cytokine
1) Confidence 0.78 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.83 Pain Relevance 0.42
However, as is evident from Table 2A, plasma IL-6 can only explain 3% of the variation in plasma YKL-40, indicating that other factors may be more important for the production/release of YKL-40.
Localization (release) of YKL-40 in plasma
2) Confidence 0.72 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.97 Pain Relevance 0.07
Interestingly, CHI3L1/YKL-40 was found in a prospective Danish population study to be predictive of ultimately developing gastrointestinal cancer.
Localization (found) of CHI3L1 associated with gastrointestinal neoplasms
3) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 1.18 Pain Relevance 0
Interestingly, CHI3L1/YKL-40 was found in a prospective Danish population study to be predictive of ultimately developing gastrointestinal cancer.
Localization (found) of YKL-40 associated with gastrointestinal neoplasms
4) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 1.17 Pain Relevance 0
CONCLUSION: To our knowledge, this is the first report demonstrating YKL-40 release by intervertebral disc culture.
Localization (release) of YKL-40 in intervertebral disc
5) Confidence 0.63 Published 2007 Journal Clin. Exp. Rheumatol. Section Body Doc Link 17631744 Disease Relevance 0.06 Pain Relevance 0
We hypothesized that macrophages in the adipose tissue might secrete YKL-40 and that plasma YKL-40 would represent macrophage infiltration in adipose tissue and serve as a marker of insulin resistance.
Localization (secrete) of YKL-40 in plasma associated with obesity and insulin resistance
6) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.23 Pain Relevance 0.36
Chitinase 3-like protein 1 (YKL-40) is a glycoprotein mainly secreted by chondrocytes which has been proposed as a possible marker of inflammation and/or cartilage alterations.
Localization (secreted) of YKL-40 in cartilage associated with inflammation
7) Confidence 0.55 Published 2007 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 17631744 Disease Relevance 0.55 Pain Relevance 0.19
YKL-40 induces maturation of monocytes to macrophages and is secreted by macrophages during late stages of differentiation and by activated macrophages [14,15].
Localization (secreted) of YKL-40 in macrophages
8) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.14 Pain Relevance 0.09
YKL-40 is a 40 kDa heparin- and chitin-binding glycoprotein which is secreted in vitro by a variety of cells.
Localization (secreted) of YKL-40
9) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.97 Pain Relevance 0.07
As in a previous study of patients with T2D [27,28], no correlation was found between hsCRP and YKL-40 implying, that YKL-40 and CRP are produced and secernated independently of each other.
Localization (secernated) of YKL-40 associated with diabetes mellitus
10) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.61 Pain Relevance 0.07

General Comments

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