INT145318

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.77
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rorb) cellular_component (Rorb)
Anatomy Link Frequency
neurons 2
neuronal 1
brain 1
motor neuron 1
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 4 93.20 High High
Hyperalgesia 5 92.16 High High
Opioid 5 91.36 High High
analgesia 2 87.68 High High
Morphine 4 87.28 High High
tail-flick 1 82.52 Quite High
Spontaneous pain 1 77.96 Quite High
amygdala 1 75.00 Quite High
Spinal cord 31 67.76 Quite High
antagonist 1 66.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 99.60 Very High Very High Very High
Hyperalgesia 5 92.16 High High
Pain 5 77.96 Quite High
Injury 66 75.96 Quite High
Cv Unclassified Under Development 1 26.96 Quite Low
Repression 3 9.44 Low Low
Spinal Cord Injury 19 5.00 Very Low Very Low Very Low
Spasticity 18 5.00 Very Low Very Low Very Low
Hypersensitivity 18 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription factor induction, however, was not detected in multiple brain regions known to respond in parallel with the same extended amygdalar structures when (1) rats are exposed to interoceptive/physical stressors, or (2) naloxone is used to precipitate abstinence in opioid dependent rats.
Neg (not) Transcription (detected) of Transcription factor in brain associated with narcan and opioid
1) Confidence 0.37 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17631915 Disease Relevance 0.69 Pain Relevance 1.57
Interestingly the non-specific general activator proteins SP1 and E2F1 have been shown to interact to promote transcription [45] and in motor neurons they can drive the transcription of the motor neuron specific transcription factor HB9 [46].
Transcription (transcription) of transcription factor in motor neuron
2) Confidence 0.11 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.08 Pain Relevance 0.03
The distribution pattern shown in Fig. 6A suggests that the RORbeta mRNA expression level is high in the sensory areas, whereas the ER81 and Nurr1 mRNA expression levels are generally high in the areas with low RORbeta mRNA expression level.
Transcription (level) of RORbeta mRNA
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
ER81 mRNA exhibited the opposite pattern, showing higher levels of expression in the areas where the RORbeta mRNA expression level was low (Fig. 1A, see also Fig. 2, panels a, e and f).
Transcription (level) of RORbeta mRNA
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Second, at single cell level, RORbeta and ER81 mRNAs were coexpressed in a subpopulation of layer 5 neurons, whereas Nurr1 and ER81 mRNAs were not colocalized.
Transcription (coexpressed) of RORbeta in neurons
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
However, RORbeta and ER81 mRNAs were expressed by a subpopulation of cortical neurons and the variations in their densities appeared to be much greater than those expected from the neuronal density of the layer of interest (Fig. 2).
Transcription (expressed) of RORbeta in neuronal
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
In the barrel field (Fig. 2, panel b), we observed a sublayer with lower expression levels of both RORbeta and ER81 mRNAs (white arrows).
Transcription (levels) of RORbeta
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
On the other hand, RORbeta and Nurr1 mRNAs were not coexpressed in the same neurons even in the areas with extensive intermingling (Fig. 3D–3F).
Neg (not) Transcription (coexpressed) of RORbeta in neurons
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0

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