INT145328

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 26.79
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib)
cytoplasm (Scrib)
Anatomy Link Frequency
colon 2
upper 1
Scrib (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 104 99.84 Very High Very High Very High
COX-2 inhibitor 11 99.62 Very High Very High Very High
Crohn's disease 14 99.48 Very High Very High Very High
agonist 54 98.84 Very High Very High Very High
Inflammation 254 97.76 Very High Very High Very High
chemokine 10 89.28 High High
antagonist 9 79.96 Quite High
abdominal pain 13 78.32 Quite High
Central nervous system 16 69.80 Quite High
Bile 16 68.48 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 1202 100.00 Very High Very High Very High
Colorectal Cancer 302 100.00 Very High Very High Very High
Inflammatory Bowel Disease 61 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Polyps 313 99.80 Very High Very High Very High
Familial Adenomatous Polyposis 1159 99.76 Very High Very High Very High
Adenoma 345 99.52 Very High Very High Very High
Disease 286 99.48 Very High Very High Very High
Toxicity 8 98.84 Very High Very High Very High
Cancer 758 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality.
Negative_regulation (removal) of CRC associated with colorectal cancer
1) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2889851 Disease Relevance 0.47 Pain Relevance 0
Randomized clinical trials evaluated guaiac-based FOBT (gFOBT) screening during a 10-year screening period and showed reduction in CRC-mortality[12].
Negative_regulation (reduction) of CRC associated with colorectal cancer
2) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.14 Pain Relevance 0
However, due to their side effects, long-term administration of these drugs for CRC prevention is not feasible.
Negative_regulation (prevention) of CRC associated with colon cancer
3) Confidence 0.14 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.09 Pain Relevance 0.22
-catenin localization also in CRC, the development of CRC is almost invariably associated with nuclear accumulation of ?
Negative_regulation (development) of CRC associated with colon cancer
4) Confidence 0.10 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.02 Pain Relevance 0
Additional support for the clonal expansion of cells in human CRC came from parallel studies in mice, which were fed dietary carcinogens and subsequently developed CRC [9].
Negative_regulation (developed) of CRC associated with colon cancer
5) Confidence 0.10 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.62 Pain Relevance 0
Today, CRC development can be prevented by prophylactic removal of the colon.
Negative_regulation (prevented) of CRC in colon associated with colon cancer
6) Confidence 0.10 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.94 Pain Relevance 0
For SNPs PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu), minor alleles appeared associated with an increase in CRC, whereas for SNPs PLA2G2A c.435+230C>T, PPARG c.1431C>T (p.His477His), they were associated with a decrease in CRC risk.
Negative_regulation (decrease) of CRC associated with colon cancer
7) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.42 Pain Relevance 0
For each polymorphism included in a combination, we therefore tested two hypotheses: 1. either we considered that the minor allele was predisposing to CRC and therefore the CRC-predisposing genotypes were 1 and 2, whereas genotype 0 was considered protective; 2. or we considered that the minor allele was associated with a decreased CRC risk, and therefore 0 was considered to be the predisposing genotype, whereas genotypes 1 and 2 were considered protective.
Negative_regulation (decreased) of CRC associated with colon cancer
8) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.51 Pain Relevance 0
In the present study, we found no effect for c.665C>T, whereas we observed an elevated risk of CRC associated with genotypes c.1286CC or c.1286AC compared to genotype c.1286AA (OR 1.21, 95%CI 1.02–1.44).
Negative_regulation (risk) of CRC associated with colon cancer
9) Confidence 0.06 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.53 Pain Relevance 0.03
Two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T, were on the contrary associated with a decrease in CRC risk.
Negative_regulation (decrease) of CRC associated with colon cancer
10) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.82 Pain Relevance 0.03
On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk.
Negative_regulation (decrease) of CRC associated with colon cancer
11) Confidence 0.05 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2585099 Disease Relevance 0.92 Pain Relevance 0.07
The respective biological impact of the five variants PTGS1 c.639C>A, IL8 c.-352T>A, MTHFR c.1286A>C, PLA2G2A c.435+230C>T, and PPARG c.1431C>T provide some clues to the predisposition to CRC associated with some of the genetic combinations that they compose.
Negative_regulation (predisposition) of CRC associated with colon cancer
12) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.46 Pain Relevance 0.15
MUTYH associated polyposis is a frequent inherited CRC predisposition, which can be mostly in a recessive form of inheritance (bi-allelic or compound mutations) but also as a dominant component, and therefore DNA screening of the MUTYH gene should look for both heterozygous and homozygous mutations [46].
Negative_regulation (predisposition) of CRC associated with colon cancer
13) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.22 Pain Relevance 0
People with CD or UC are predisposed to developing CRC, an outcome that
Negative_regulation (developing) of CRC associated with inflammatory bowel disease, crohn's disease and colon cancer
14) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.59 Pain Relevance 0.25
represents a potential therapeutic target for CRC and IBD chemoprevention.
Negative_regulation (chemoprevention) of CRC associated with inflammatory bowel disease and colon cancer
15) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 0.95 Pain Relevance 0.17
However, although relatively safe in terms of gastrointestinal toxicity, the long-term use of COX-2 inhibitors in the setting of CRC prevention carries a risk, albeit small, of serious cardiovascular complications [112].
Negative_regulation (prevention) of CRC associated with toxicity, colon cancer and cox-2 inhibitor
16) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.50 Pain Relevance 0.05
So, if the colon is left intact, the majority of patients with FAP eventually develop CRC by the ages 40-50 years.
Negative_regulation (develop) of CRC in colon associated with colon cancer and familial adenomatous polyposis
17) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 2.22 Pain Relevance 0.06
In a subset of individuals, a MUTYH mutation causes a recessively inherited polyposis condition, MUTYH-associated polyposis (MAP), which is characterized by a slightly increased risk of developing CRC and polyps/adenomas in both the upper and lower gastrointestinal tract.
Negative_regulation (developing) of CRC in upper associated with adenoma, colon cancer and polyps
18) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2772987 Disease Relevance 2.47 Pain Relevance 0.12
In fact, randomized clinical trials indicated that FOBT is not very reliable and that it only reduces CRC mortality by 30% [3,11].

2.2.

Negative_regulation (reduces) of CRC associated with colorectal cancer
19) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.00 Pain Relevance 0.08
The mean and median diagnostic delay (SD and SE) for early and late stage CRC separately are also shown in Table 3 and 4.
Negative_regulation (shown) of CRC associated with colorectal cancer
20) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2907342 Disease Relevance 0.86 Pain Relevance 0.08

General Comments

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