INT14536

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.54
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brainstem 3
spinal cord 1
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 2 99.80 Very High Very High Very High
Intracerebroventricular 1 99.60 Very High Very High Very High
Spinal cord 8 99.20 Very High Very High Very High
antinociception 4 99.02 Very High Very High Very High
medulla 6 98.56 Very High Very High Very High
Morphine 2 97.04 Very High Very High Very High
Enkephalin 2 95.44 Very High Very High Very High
Antinociceptive 5 90.52 High High
Somatostatin 2 88.64 High High
Neuropeptide 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Disease 6 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antinociception induced by TRH does not appear to depend on the biotransformation of TRH to its metabolites since they are less active than TRH itself.
Positive_regulation (biotransformation) of Gene_expression (biotransformation) of TRH associated with antinociception
1) Confidence 0.50 Published 1987 Journal Pain Section Abstract Doc Link 3118323 Disease Relevance 0 Pain Relevance 0.22
C.NMTA-induced antinociception was significantly potentiated by simultaneously intracerebroventricular or intraperitoneal injection of TRH (approximately 20-50%) in a dose-dependent manner, whereas the effect of morphine was not influenced significantly by TRH.
Positive_regulation (injection) of Gene_expression (injection) of TRH associated with antinociception, intracerebroventricular and morphine
2) Confidence 0.50 Published 1984 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6143808 Disease Relevance 0 Pain Relevance 0.58
Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla).
Positive_regulation (increased) of Gene_expression (levels) of thyrotropin releasing hormone in brainstem associated with medulla, disease, spinal cord and substance p
3) Confidence 0.38 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697212 Disease Relevance 0.27 Pain Relevance 0.55
Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla).
Positive_regulation (increased) of in spinal cord Gene_expression (levels) of thyrotropin releasing hormone in brainstem associated with medulla, disease, spinal cord and substance p
4) Confidence 0.13 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697212 Disease Relevance 0.27 Pain Relevance 0.55

General Comments

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