INT145384

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.40
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTA) extracellular space (LTA) extracellular region (LTA)
cell-cell signaling (LTA)
Anatomy Link Frequency
arm 1
neutrophils 1
LTA (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 78 100.00 Very High Very High Very High
antagonist 31 99.60 Very High Very High Very High
Antihistamine 12 98.84 Very High Very High Very High
aspirin 9 94.92 High High
Inflammation 46 80.88 Quite High
cytokine 19 79.84 Quite High
Migraine 2 50.00 Quite Low
agonist 4 41.12 Quite Low
Inflammatory response 16 39.68 Quite Low
chemokine 1 37.04 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 25 99.76 Very High Very High Very High
Diabetes Complications 16 99.60 Very High Very High Very High
Urticaria 62 99.52 Very High Very High Very High
Bacterial Respiratory Disease 1 98.44 Very High Very High Very High
Diabetes Mellitus 153 97.60 Very High Very High Very High
Asthma 157 96.24 Very High Very High Very High
Age-related Macular Degeneration 11 88.08 High High
Renal Disease 42 84.24 Quite High
INFLAMMATION 71 80.88 Quite High
Headache 6 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several candidate genes on the short arm of chromosome 6 including the HLA locus, TNF, LTA and AGER could be associated with late diabetic complications.
LTA Binding (associated) of in arm associated with diabetes complications
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429972 Disease Relevance 0.42 Pain Relevance 0
The association patterns between diabetic complications and polymorphisms in LTA, TNF, AGER and HLA was complex and none of the studied polymorphism was associated with all diabetic complications in either type 1 or type 2 diabetic patients.
LTA Binding (associated) of associated with diabetes mellitus and diabetes complications
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.15 Pain Relevance 0
We performed a chromatin immunoprecipitation (ChIP) assay and an electrophoretic mobility shift assay (EMSA) to identify differential protein-DNA binding of LTA-294.
LTA Binding (binding) of
3) Confidence 0.29 Published 2007 Journal Headache Section Body Doc Link 17635597 Disease Relevance 0.18 Pain Relevance 0
While the association of LT receptor antagonists and H1-antihistamine drugs in patients suffering from idiopathic urticaria, according to the same AA., would not add any beneficial effect, compared with the antihistamine monotherapy [28].
LT Binding (association) of associated with urticaria, antihistamine and antagonist
4) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945673 Disease Relevance 0.76 Pain Relevance 0.31
Monosialoganglioside GM1 (GM1) has a high binding affinity for heat labile toxin (LT) and was exploited in the assay to detect anti-heat labile specific IgG.
LT Binding (affinity) of
5) Confidence 0.23 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0 Pain Relevance 0
Monosialoganglioside GM1 (GM1) has a high binding affinity for heat labile toxin (LT) and was exploited in the assay to detect anti-heat labile specific IgG.
LT Binding (binding) of
6) Confidence 0.23 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0 Pain Relevance 0
As with most GWA studies, the association of LTA with myocardial infarction was an unexpected finding and suggests novel therapeutic approaches.
LTA Binding (association) of associated with myocardial infarction
7) Confidence 0.19 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717811 Disease Relevance 0.55 Pain Relevance 0
The TLR1/TLR2 heterodimer recognizes tri-acyl lipopeptides while TLR2/TLR6 recognizes lipotechoic acid (LTA) and di-acyl lipopeptides produced by mycoplasma [8-10].
LTA Binding (recognizes) of associated with bacterial respiratory disease
8) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.18 Pain Relevance 0.08
Also, according to the 1997 guidelines, the LT modifiers were considered as an alternative to low doses of ICS, cromolyn, nedocromil, or theophylline for patients ?
LT Binding (cromolyn) of associated with corticosteroid
9) Confidence 0.02 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.80 Pain Relevance 0.24
The non-cysteinyl LT, LTB4, binds to the B leukotriene (BLT) receptor, which is responsible for recruitment and activation of leukocytes, in particular neutrophils (Yokomizo et al 1997; Devillier et al 1999a).
LT Binding (binds) of in neutrophils
10) Confidence 0.02 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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