INT145425

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.93
Pain Relevance 12.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP1) nucleus (NLRP1) intracellular (NLRP1)
enzyme binding (NLRP1) cytoplasm (NLRP1)
Anatomy Link Frequency
NAc 6
band 1
T cells 1
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 384 100.00 Very High Very High Very High
Nucleus accumbens 271 100.00 Very High Very High Very High
Ventral tegmentum 132 100.00 Very High Very High Very High
cocaine 22 99.98 Very High Very High Very High
imagery 76 99.96 Very High Very High Very High
Analgesic 40 99.52 Very High Very High Very High
analgesia 26 99.52 Very High Very High Very High
gABA 14 98.94 Very High Very High Very High
antagonist 75 98.76 Very High Very High Very High
depression 232 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Treatment-resistant Depression (TRD) 16 98.40 Very High Very High Very High
Pain 314 97.88 Very High Very High Very High
Sepsis 34 97.64 Very High Very High Very High
Apoptosis 152 95.52 Very High Very High Very High
Urological Neuroanatomy 15 93.56 High High
Cystic Fibrosis 1 92.96 High High
Attention Deficit Hyperactivity Disorder 62 92.24 High High
INFLAMMATION 35 92.08 High High
Atelectasis 17 91.36 High High
Repression 164 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the effect of UV irradiation on the Nalp1 and Nalp3 inflammasome components and on Nod molecules seems to be rather complex.
Positive_regulation (irradiation) of Nalp1
1) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.61 Pain Relevance 0
Employing functional molecular imaging, activation of NAC dopamine (DA) release was observed during placebo administration and related to its anticipated effects, perception-anticipation mismatches, and placebo effect development.
Positive_regulation (activation) of NAC dopamine in NAC associated with nucleus accumbens, dopamine and imagery
2) Confidence 0.46 Published 2007 Journal Neuron Section Abstract Doc Link 17640532 Disease Relevance 0 Pain Relevance 0.46
While UV-B irradiation exerted a downregulation of both Nalp and Nod mRNAs as well as those of inflammasome components in HCE-T cells, longer incubation of the cells after exposure resulted in recovery or upregulation only of the Nalp sensors.
Positive_regulation (upregulation) of Nalp in T cells
3) Confidence 0.38 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.12
These anatomical studies seem to agree with other studies showing contralateral activation in the NAc [45,55].
Positive_regulation (activation) of NAc in NAc associated with nucleus accumbens
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2883978 Disease Relevance 0.50 Pain Relevance 1.25
A parallel study on NAc activation in response to the direct effects of the analgesic (pain offset) morphine, showed the same increased (rewarding) BOLD signal in the structure [56].
Positive_regulation (activation) of NAc in NAc associated with pain, nucleus accumbens, analgesic and morphine
5) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2883978 Disease Relevance 0.71 Pain Relevance 1.42
Importantly, responses in the NAc and VTA were strongly correlated pointing to an association between dopamine release and NAc response to music.
Positive_regulation (responses) of NAc in NAc associated with ventral tegmentum, nucleus accumbens and dopamine
6) Confidence 0.29 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.22 Pain Relevance 0.59
Chronic stimulation of the NAc has recently been carried out in three TRD patients [208].
Positive_regulation (stimulation) of NAc associated with nucleus accumbens and depression
7) Confidence 0.22 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.47 Pain Relevance 0.51
High voltage electrical stimulation of the NAc in both animals and humans has been found to elicit pleasurable and sexual responses [68,69] and ejaculation in human males has been found to correlate with activation of the VTA [64].


Positive_regulation (stimulation) of NAc associated with ventral tegmentum and nucleus accumbens
8) Confidence 0.22 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.51 Pain Relevance 0.41
First, NALP1 was induced in U versus WT but repressed in USTS versus WTSTS.
Positive_regulation (induced) of NALP1
9) Confidence 0.21 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.51 Pain Relevance 0.05
In the present study we identified no positive effects of NAC.
Neg (no) Positive_regulation (effects) of NAC
10) Confidence 0.19 Published 2004 Journal Crit Care Section Body Doc Link PMC522835 Disease Relevance 1.24 Pain Relevance 0.14
Electrical stimulation of the NAc and the septum has been found to elicit feelings of sexual pleasure and orgasm in humans [69,206,207].
Positive_regulation (stimulation) of NAc associated with nucleus accumbens
11) Confidence 0.15 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.25 Pain Relevance 0.57
Neuroimaging studies in humans have shown that rewarding stimuli activate dopaminergic cells in the VTA [64-66] eliciting an increase of dopamine release in the NAc [67].
Positive_regulation (increase) of NAc associated with nucleus accumbens, ventral tegmentum and dopamine
12) Confidence 0.15 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.32 Pain Relevance 0.42
NAC dopamine release induced by placebo analgesia is related to expectation of analgesia.
Positive_regulation (induced) of NAC dopamine release in NAC associated with nucleus accumbens, dopamine and analgesia
13) Confidence 0.10 Published 2009 Journal Neurosci Bull Section Abstract Doc Link 19784082 Disease Relevance 0.46 Pain Relevance 2.08
In vivo microdialysis showed that the same doses of Gabapentin produced a modest increase (approximately 50%, p < 0.05) in extracellular NAc GABA levels, but failed to alter either basal or cocaine-enhanced NAc DA.
Neg (failed) Positive_regulation (enhanced) of NAc associated with nucleus accumbens, dopamine, gaba, gabapentin and cocaine
14) Confidence 0.09 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.31 Pain Relevance 1.68
Thus, despite its widespread use, few data are available to support NAC as a mucolytic agent.
Positive_regulation (support) of NAC
15) Confidence 0.04 Published 2008 Journal Crit Care Section Body Doc Link PMC2447567 Disease Relevance 0.64 Pain Relevance 0.08
There is some evidence that psychostimulants activate the ventral tegmental area (VTA), nucleus accumbens (NAc), and prefrontal cortex (PFC).


Positive_regulation (activate) of NAc in NAc associated with nucleus accumbens and ventral tegmentum
16) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Abstract Doc Link PMC1360669 Disease Relevance 0.18 Pain Relevance 0.31
The above data show that the stimulation of P2 receptors in the NAc may not mediate motivational behavior per se.
Positive_regulation (stimulation) of NAc associated with nucleus accumbens
17) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.76
Therefore, P2 receptor agonists may modulate the activity of dopaminergic cell bodies in the VTA both by local direct stimulation and/or indirect inhibitory control via dopamine release and subsequent dopamine D2 receptor stimulation in the NAc.
Positive_regulation (stimulation) of NAc associated with nucleus accumbens, ventral tegmentum, dopamine and agonist
18) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.67
The enhanced activity of dopaminergic afferents to the NAc induced by P2 receptor stimulation is accompanied by an enhancement of the electrical activity of this area — an elevation of the absolute EEG power and the power in the alpha-frequency band (8–13 Hz) [84, 85].
Positive_regulation (induced) of NAc in band associated with nucleus accumbens
19) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.58

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