INT145426

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2011
Negated 1
Speculated 7
Reported most in Body
Documents 185
Total Number 195
Disease Relevance 106.76
Pain Relevance 27.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
lenses 9
neurons 5
cochlear 4
respiratory 4
liver 4
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1556 100.00 Very High Very High Very High
Kinase C 432 100.00 Very High Very High Very High
Inflammatory mediators 94 100.00 Very High Very High Very High
ischemia 501 99.98 Very High Very High Very High
qutenza 590 99.78 Very High Very High Very High
substance P 39 99.76 Very High Very High Very High
Glutamate 17 99.76 Very High Very High Very High
Inflammatory response 231 99.40 Very High Very High Very High
agonist 322 99.36 Very High Very High Very High
tolerance 362 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1852 100.00 Very High Very High Very High
Lung Injury 232 100.00 Very High Very High Very High
Myocardial Infarction 70 100.00 Very High Very High Very High
Stress 1423 99.98 Very High Very High Very High
Cv Unclassified Under Development 1107 99.98 Very High Very High Very High
Shock 40 99.98 Very High Very High Very High
Injury 1220 99.96 Very High Very High Very High
Reperfusion Injury 378 99.96 Very High Very High Very High
Disease 1360 99.92 Very High Very High Very High
Adult Respiratory Distress Syndrome 86 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, significant increases in ROS were not seen in irradiated lenses for the first 3 months after X-irradiation, but rather, did not appear until 6 months following X-irradiation, and further, must have been produced by some continuous process such as damaged mitochondria or other sources [1,6,76-78].
Positive_regulation (increases) of ROS in lenses
1) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.28 Pain Relevance 0
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Positive_regulation (elevated) of ROS in cochlear associated with depression
2) Confidence 0.48 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.43 Pain Relevance 0.11
The elevated ROS can lead to metabolically initiated structural damage to sensitive cochlear structures [17].
Positive_regulation (elevated) of ROS in cochlear
3) Confidence 0.48 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.05 Pain Relevance 0
Using DNA and ROS specific vital fluorescent dyes, and laser scanning confocal microscopy we have previously described 4 changes in aging rodent lenses: 1) a significantly decreased density of surface LECs in old compared to younger lenses in both mice and rats; 2) strong increases in cortical nuclei and DNA fragments in the secondary lens fibers of old rodent lenses; 3) increased cortical ROS in old rodent lenses; and 4) increased cataract concomitantly with the cortical DNA and ROS increases [12,19,20].
Positive_regulation (increases) of ROS in lenses associated with aging and cataract
4) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.38 Pain Relevance 0
The dose of X- radiation, as used here, has been shown to induce primary damage in the LECs through induction of ROS, and/or by direct energy transfer to DNA and other macromolecules in the lens [12,33-38].
Positive_regulation (induction) of ROS in lens
5) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.49 Pain Relevance 0
Using DNA- and ROS-specific vital fluorescent dyes, and laser scanning confocal microscopy we have previously described 4 changes in the aging rodent lenses: 1) a significantly decreased density of surface LECs in lenses from old compared to younger mice and rats; 2) a very large increase in retained cortical nuclei and DNA fragments in the secondary lens fibers of old rodent lenses; 3) increased cortical ROS in old rodent lenses; 4) increased cataract concomitantly with the cortical DNA and ROS increases.
Positive_regulation (increased) of ROS in lenses associated with aging and cataract
6) Confidence 0.38 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2925908 Disease Relevance 0.43 Pain Relevance 0
We previously reported high levels of ROS in old cataractous mouse and rat lenses stained vitally with DHR [19,20].
Positive_regulation (levels) of ROS in lenses
7) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.41 Pain Relevance 0
Such excess ROS would be expected to damage the DNA, producing 8-OH-dG adducts [55].
Positive_regulation (excess) of ROS
8) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.19 Pain Relevance 0
In the present study, X- irradiated lenses and control lenses are compared as a function of time for the 4 changes we previously observed in old lenses: 1) LEC loss, 2) decreased ability to degrade DNA in secondary lens fibers, 3) excessive ROS accumulation and ROS damage in the cortex, and 4) appearance of increasing opacities eventuating in cataracts.


Positive_regulation (accumulation) of ROS in lenses associated with cataract
9) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.33 Pain Relevance 0
Using DNA and ROS specific vital fluorescent dyes, and laser scanning confocal microscopy we have previously described 4 changes in aging rodent lenses: 1) a significantly decreased density of surface LECs in old compared to younger lenses in both mice and rats; 2) strong increases in cortical nuclei and DNA fragments in the secondary lens fibers of old rodent lenses; 3) increased cortical ROS in old rodent lenses; and 4) increased cataract concomitantly with the cortical DNA and ROS increases [12,19,20].
Positive_regulation (increased) of ROS in lenses associated with aging and cataract
10) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.36 Pain Relevance 0
If LEC loss and the accumulation of cortical nuclear fragments and ROS are instrumental in ARC progress, exogenous agents capable of damaging LECs, and inducing oxidative damage, would be expected to produce the same series of events in an accelerated fashion.
Positive_regulation (accumulation) of ROS associated with aids-related complex
11) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.56 Pain Relevance 0
In the present study, X- irradiated lenses and control lenses are compared as a function of time for the 4 changes we previously observed in old lenses: 1) LEC loss, 2) decreased ability to degrade DNA in secondary lens fibers, 3) excessive ROS accumulation and ROS damage in the cortex, and 4) appearance of increasing opacities eventuating in cataracts.


Positive_regulation (accumulation) of ROS in lenses associated with cataract
12) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.33 Pain Relevance 0
One can suggest that following furosemide injection, the resulting depression of the cochlear amplifier leads to the synthesis of lower levels of ROS, with less metabolically induced structural damage; while the damage due to elevated levels of ROS is reduced by the anti-oxidants.
Positive_regulation (elevated) of ROS in cochlear associated with depression
13) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.32 Pain Relevance 0.08
Elevated levels of ROS are produced as part of the metabolic processes involved in maintaining adequate electro-chemical gradients (with greater metabolic demand) required to continue auditory transduction in the presence of the noise exposure.
Positive_regulation (levels) of ROS
14) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0 Pain Relevance 0.05
Therefore it is possible that other factors (in addition to the elevated ROS levels) such as necrotic and/or apoptotic damage may be contributing to the NIHL.
Positive_regulation (elevated) of ROS associated with noise-induced hearing loss and apoptosis
15) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.51 Pain Relevance 0.08
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Positive_regulation (induced) of ROS in cochlear associated with depression
16) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.43 Pain Relevance 0.11
In this case, only smooth muscles exist in the blood vessel and they are directly damaged by the generated ROS.
Positive_regulation (generated) of ROS in blood vessel
17) Confidence 0.32 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.49 Pain Relevance 0.13
The same diseases can be caused when the inflammatory response is extremely high, since the ROS, including peroxyl radicals (ROO·), OH·, O2·-, H2O2 and hypochlorous acid (HOCl), and RNS, including nitric oxide (·NO) and peroxynitrite anion (ONOO-), are increased.
Positive_regulation (increased) of ROS associated with inflammatory response and disease
18) Confidence 0.32 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.73 Pain Relevance 0.35
Represented with numerical data at the 30 minute time point, the ROS fluorescent intensity for the capsaicin treated group (1037.57 ± 72.15 arbitrary units, n = 117, P < 0.01) was increased compared to the untreated group (693.24 ± 75.84, n = 49, P < 0.01); and ROS was increased in the resiniferatoxin treated group (1524.56 ± 97.73, n = 104, P < 0.001) compared with the untreated group (980.61 ± 140.60, n = 80, P < 0.001) (Fig. 4C, D).
Positive_regulation (increased) of ROS associated with qutenza
19) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.19 Pain Relevance 0.63
ROS and RNS are generated as the result of antagonizing infectious pathogenic bacteria in those cells.
Positive_regulation (generated) of ROS
20) Confidence 0.26 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.65 Pain Relevance 0.18

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