INT145451

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.00
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
plasma 2
nerves 2
colon 1
brain 1
large intestine 1
Pyy (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 12 99.84 Very High Very High Very High
antagonist 105 93.12 High High
qutenza 6 88.92 High High
tolerance 32 69.28 Quite High
Bile 5 59.04 Quite High
Neurotransmitter 7 49.08 Quite Low
Potency 4 44.08 Quite Low
member 8 2 41.04 Quite Low
agonist 61 31.00 Quite Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 98.46 Very High Very High Very High
Targeted Disruption 34 89.60 High High
Weight Gain 2 85.76 High High
Diabetes Mellitus 9 80.32 Quite High
Impaired Glucose Tolerance 32 69.92 Quite High
Body Weight 7 69.76 Quite High
Adhesions 5 68.08 Quite High
Obesity 7 48.00 Quite Low
Hyperinsulinism 5 34.40 Quite Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the expression pattern of Gpr119 is very similar to that of PYY/GLP-1 containing L cells (Chu et al., 2008), suggesting that Gpr119 stimulation could cause significant PYY-related responses as well as GLP-1-mediated effects in the colon and elsewhere.
Positive_regulation (cause) of PYY in colon
1) Confidence 0.43 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.16 Pain Relevance 0.06
NPY released from other non-adrenergic, non-cholinergic secretomotor nerves could auto-inhibit NPY release by Y2 receptor activation and local NPY, NPY(3–36), PYY, or PYY(3–36) could act on these neuronal Y2 receptors to modulate ongoing mucosal electrolyte secretion.
Positive_regulation (activation) of PYY in nerves
2) Confidence 0.36 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.07 Pain Relevance 0
The switching of receptor activities is likely to be important in modulating digestive behavior and in initiating satiety consequent to postprandial increases in plasma PYY and PYY(3–36).
Positive_regulation (increases) of PYY in plasma
3) Confidence 0.33 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.15 Pain Relevance 0.03
The switching of receptor activities is likely to be important in modulating digestive behavior and in initiating satiety consequent to postprandial increases in plasma PYY and PYY(3–36).
Positive_regulation (increases) of PYY in plasma
4) Confidence 0.33 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.15 Pain Relevance 0.03
Therefore, we set out to establish whether endogenous PYY was responsible for Y1 absorptive tone and NPY-mediated Y2 tone, making use of single (PYY?
Spec (whether) Positive_regulation (endogenous) of PYY
5) Confidence 0.33 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.09 Pain Relevance 0
NPY released from other non-adrenergic, non-cholinergic secretomotor nerves could auto-inhibit NPY release by Y2 receptor activation and local NPY, NPY(3–36), PYY, or PYY(3–36) could act on these neuronal Y2 receptors to modulate ongoing mucosal electrolyte secretion.
Positive_regulation (activation) of PYY in nerves
6) Confidence 0.31 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.07 Pain Relevance 0
The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake.
Positive_regulation (activation) of PYY associated with cholecystokinin
7) Confidence 0.27 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.07 Pain Relevance 0.39
The aim of the present study was to determine the role of the apolipoprotein (apo) A-IV-cholecystokinin (CCK)(1) receptor (CCK(1)R) pathway in exogenous PYY(3-36)-induced activation of the gut-brain axis and inhibition of gastric emptying and food intake.
Positive_regulation (activation) of PYY in brain associated with cholecystokinin and disorder of lipid metabolism
8) Confidence 0.27 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.17 Pain Relevance 0.18
A similar increasing sensitivity to exogenous PYY and NPY has also been described from the small to the large intestine of the mouse (Cox et al., 2001).
Positive_regulation (increasing) of PYY in large intestine
9) Confidence 0.18 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.08 Pain Relevance 0.05

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