INT145472

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Dnahc8) cytoskeleton (Dnahc8) cilium (Dnahc8)
molecular_function (Dnahc8) biological_process (Dnahc8) cytoplasm (Dnahc8)
D2Mit212 (Mus musculus)
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 98.60 Very High Very High Very High
Cannabinoid receptor 4 98.18 Very High Very High Very High
Cannabinoid 8 93.44 High High
opioid receptor 2 87.16 High High
narcan 6 85.92 High High
Endogenous opioid 2 63.16 Quite High
Delta-9-tetrahydrocannabinol 2 56.60 Quite High
cannabis 2 55.44 Quite High
agonist 2 48.40 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, pre-incubation with 0.5 microg of pertussis toxin (G(i/o) protein blocker) completely abolished the enhancement of ouabain-sensitive Na(+),K(+)-ATPase activity induced by WIN55,212-2.
WIN55,212-2 Positive_regulation (induced) of ATPase associated with bordatella infection
1) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.10 Pain Relevance 0.36
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM-251) (10 nM), a CB(1) cannabinoid receptor selective antagonist, had not effect per se but antagonized the enhancement of Na(+),K(+)-ATPase activity induced by both, WIN55,212-2 and triangle up(9)-THC.
WIN55,212-2 Positive_regulation (induced) of ATPase associated with cannabinoid receptor and antagonist
2) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.06 Pain Relevance 0.45

General Comments

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