INT145473

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.06
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mastl, Dnahc8) cytoskeleton (Mastl, Dnahc8) cilium (Dnahc8)
mitosis (Mastl) ATPase activity (Dnahc8) nucleus (Mastl)
Mastl (Mus musculus)
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 12 99.36 Very High Very High Very High
narcan 9 98.98 Very High Very High Very High
antagonist 6 98.60 Very High Very High Very High
Cannabinoid receptor 6 98.18 Very High Very High Very High
agonist 3 96.52 Very High Very High Very High
cannabis 3 89.52 High High
Delta-9-tetrahydrocannabinol 3 89.16 High High
Endogenous opioid 3 82.16 Quite High
opioid receptor 3 81.76 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM-251) (10 nM), a CB(1) cannabinoid receptor selective antagonist, had not effect per se but antagonized the enhancement of Na(+),K(+)-ATPase activity induced by both, WIN55,212-2 and triangle up(9)-THC.
THC Positive_regulation (induced) of ATPase associated with cannabinoid receptor and antagonist
1) Confidence 0.07 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.06 Pain Relevance 0.46
Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and delta(9)-THC.
THC Positive_regulation (activation) of ATPase associated with cannabinoid and narcan
2) Confidence 0.07 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17644088 Disease Relevance 0 Pain Relevance 0.41
Incubation in vitro of the synaptosomes with WIN55,212-2 (0.1 pM-10 microM) or triangle up(9)-THC (0.1 pM-0.1 microM), in a concentration-dependent manner, stimulated ouabain-sensitive Na(+),K(+)-ATPase activity.
THC Positive_regulation (stimulated) of ATPase
3) Confidence 0.07 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0 Pain Relevance 0.46

General Comments

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