INT14548

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.43
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
spinal cord 4
nerve 2
brainstem 2
spinal 1
STR 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 52 100.00 Very High Very High Very High
qutenza 37 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Spinal cord 26 99.78 Very High Very High Very High
Inflammation 17 99.62 Very High Very High Very High
Calcitonin gene-related peptide 7 98.96 Very High Very High Very High
gABA 10 98.60 Very High Very High Very High
antagonist 24 98.44 Very High Very High Very High
Dopamine 8 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 99.62 Very High Very High Very High
Ganglion Cysts 2 99.56 Very High Very High Very High
Nociception 2 97.62 Very High Very High Very High
Hyperalgesia 2 95.88 Very High Very High Very High
Respiratory Disease 1 91.48 High High
Asthma 5 89.52 High High
Disease 1 86.16 High High
Chronic Obstructive Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Cystic Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the method seems to be less suitable for studies of tachykinin release in response to electrical activation engaging only a few spinal segments or in response to natural noxious stimuli.
Localization (release) of tachykinin in spinal
1) Confidence 0.78 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.49
The aim of the present study was to establish an experimental model, previously used in cat, for studying tachykinin release from the rat spinal cord in vivo and to compare the results with those obtained in vitro.
Localization (release) of tachykinin in spinal cord associated with spinal cord
2) Confidence 0.78 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.37
Tachykinin release from rat spinal cord in vitro and in vivo in response to various stimuli.
Localization (release) of Tachykinin in spinal cord associated with qutenza and spinal cord
3) Confidence 0.78 Published 1988 Journal Regul. Pept. Section Title Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.68
Localization of beta pre-protachykinin mRNA in nodose ganglion.
Localization (Localization) of beta pre-protachykinin mRNA in ganglion associated with ganglion cysts
4) Confidence 0.55 Published 1991 Journal Neuropeptides Section Title Doc Link 1722284 Disease Relevance 0.18 Pain Relevance 0.18
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Localization (release) of PPT in STR associated with dopamine
5) Confidence 0.41 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.59
In the isolated guinea-pig bronchus, electrical field stimulation and capsaicin induced non-cholinergic contractions which are known to be caused by tachykinin release from afferent nerve terminals.
Localization (release) of tachykinin in nerve associated with qutenza
6) Confidence 0.35 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1697404 Disease Relevance 0 Pain Relevance 0.86
These results provide evidence for a presynaptic control of nociceptive primary afferent neurons by GABA(B) but not GABA(A) receptors in the superficial laminae of the spinal cord, limiting tachykinin release.
Localization (release) of tachykinin in spinal cord associated with nociception, gaba and spinal cord
7) Confidence 0.28 Published 2001 Journal Neuroscience Section Abstract Doc Link 11274791 Disease Relevance 0.10 Pain Relevance 0.96
We deduce that endocytosis in the presence of monensin was stimulated by the release of tachykinins from intrinsic nerve endings, based on the following evidence: when endogenous release of tachykinin was blocked using a high magnesium/low calcium solution, or binding of tachykinins to the receptor was prevented using 10(-6) M SR140333, the intracellular receptor immunoreactivity remained at approximately 40%.
Localization (release) of tachykinin in nerve
8) Confidence 0.20 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336084 Disease Relevance 0 Pain Relevance 0.27
The tachykinin NK2 receptor-mediated secretion was inhibited by i.c.v. injections of antagonists of the CGRP1 receptor (human CGRP fragment 8-37, 15 nmol) and non-N-methyl-D-aspartate (non-NMDA)-type glutamate receptor (6-cyano-7-nitroquinoxaline-2,3-dione, 10.9 nmol); the values were 30.8+/-29.8 and 5.7+/-16.9 microEq HCl, respectively.
Localization (secretion) of tachykinin associated with glutamate receptor, antagonist and calcitonin gene-related peptide
9) Confidence 0.16 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.61
Binding of [125I]-Bolton-Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK(1), NK(2) and NK(3) receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS.
Localization (localised) of tachykinin NK in brainstem associated with medulla, qutenza and substance p
10) Confidence 0.15 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850591 Disease Relevance 0 Pain Relevance 0.50
Binding of [125I]-Bolton-Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK(1), NK(2) and NK(3) receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS.
Localization (localised) of tachykinin NK in brainstem associated with medulla, qutenza and substance p
11) Confidence 0.15 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850591 Disease Relevance 0 Pain Relevance 0.50
Five days after the induction of inflammation, capsaicin-evoked release of immunoreactive substance P (iSP) and immunoreactive calcitonin gene-related peptide (iCGRP) was increased approximately 2-fold in slices of cord tissue from the side ipsilateral to CFA injection, compared to spinal cord slices from the non-inflamed side.
Localization (release) of immunoreactive substance P in spinal cord associated with qutenza, inflammation, spinal cord, calcitonin gene-related peptide and substance p
12) Confidence 0.07 Published 1998 Journal Pain Section Abstract Doc Link 9822210 Disease Relevance 0.80 Pain Relevance 1.31
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Background

Localization (secretion) of tachykinin in platelet
13) Confidence 0.04 Published 2008 Journal J Occup Med Toxicol Section Title Doc Link PMC2278150 Disease Relevance 0.35 Pain Relevance 0.16

General Comments

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