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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.10
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 1 98.88 Very High Very High Very High
Desipramine 3 93.20 High High
Dextromethorphan 35 91.16 High High
antidepressant 4 89.76 High High
fluoxetine 2 88.72 High High
Paracetamol 4 86.72 High High
Potency 4 68.40 Quite High
tricyclic antidepressant 2 66.08 Quite High
carbamazepine 1 51.60 Quite High
Dopamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 359 94.84 High High
Hypotension 2 88.88 High High
Coronary Heart Disease 6 87.88 High High
Hepatotoxicity 4 66.92 Quite High
Cognitive Disorder 41 64.24 Quite High
Anxiety Disorder 14 58.84 Quite High
Hyperuricemia 31 58.08 Quite High
Drug Dependence 37 57.12 Quite High
Crystal Associated Disease 54 56.64 Quite High
Schizophrenia 40 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the study was to investigate the influence of sodium ozagrel on CYP2D6 (cytochromeP450 2D6) activity.
Spec (investigate) Regulation (influence) of CYP2D6
1) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17651725 Disease Relevance 0 Pain Relevance 0.32
Effect of sodium ozagrel on the activity of rat CYP2D6.
Regulation (Effect) of CYP2D6
2) Confidence 0.27 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17651725 Disease Relevance 0 Pain Relevance 0.41
Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats

Flos carthami is a traditional Chinese herbal medicine.

Regulation (Effects) of CYP2D6
3) Confidence 0.27 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Title Doc Link PMC2994065 Disease Relevance 0.09 Pain Relevance 0.07
Based on the in vitro study that showed febuxostat had a weak inhibitory effect on CYP2D6, but no effect on CYP1A2, CYP2C9, CYP2C19 or CYP3A4, Khosravan et al (2005b) examined the effect of multiple doses of febuxostat 120 mg daily on the pharmacokinetics of desipramine, a substrate for CYP2D6.
Regulation (effect) of CYP2D6 associated with desipramine
4) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0.09
The importance of CYP2D6 and CYP3A4 in sertindole clearance is underlined by its interactions with potent inhibitors of these isoenzymes.
Regulation (importance) of CYP2D6
5) Confidence 0.10 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939763 Disease Relevance 0.09 Pain Relevance 0.11
A recent review on drug interactions in the treatment of ADHD concluded that methylphenidate appears to be more implicated in pharmacokinetic interactions suggestive of possible metabolic inhibition, while amphetamine was more involved in pharmacodynamic interactions and could potentially be influenced by medications affecting cytochrome P450 (CYP2D6) [304].
Regulation (affecting) of CYP2D6 associated with attention deficit hyperactivity disorder
6) Confidence 0.05 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2942810 Disease Relevance 0.69 Pain Relevance 0.20

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