INT145490

Context Info Confidence 0.36 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.29 Pain Relevance 0.09

structural molecule activity (KRT76) cytoskeleton organization (KRT76)

KRT76 (Homo sapiens)

Pain Link Frequency Relevance Heat local anesthetic 1 92.40 medulla 7 5.00 Inflammation 6 5.00 Bile 1 5.00 Chronic pancreatitis 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 19 92.04 Apoptosis 12 85.84 Disease 13 57.28 Ichthyosis 1 55.64 Cancer 85 15.28 Adenocarcinoma 46 5.00 Skin Cancer 29 5.00 Carcinoma 22 5.00 Metastasis 16 5.00 Injury 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antibodies against these corneal keratins described include MAb AE5 (PROGEN, Heidelberg, Germany) which reacts with K3 and additionally with the related K76 (formerly K2p; see below; Collin et al. 1992b) and MAb AK12 which recognizes K12 (Chaloin-Dufau et al. 1993).

K2p Binding (reacts) of

1) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.20 Pain Relevance 0

This goal will be facilitated by characterization of native K2P channel isoforms, their pharmacological properties and tissue-specific expression patterns.

K2P Binding (characterization) of

2) Confidence 0.09 Published 2007 Journal Cell Biochem. Biophys. Section Abstract Doc Link 17652773 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

This test has worked.