INT145514

Context Info Confidence 0.32 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.23 Pain Relevance 0.72

mitochondrion (Nefh)

Anatomy Link Frequency neurites 2 dendrites 1 IB4 1 Nefh (Mus musculus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 3 100.00 Cancer pain 6 88.96 Neurotransmitter 10 83.64 Root ganglion neuron 1 75.00 Pain 4 72.00 antagonist 1 60.72 Analgesic 1 57.56 Multiple sclerosis 6 5.00 imagery 5 5.00 dorsal root ganglion 3 5.00

Disease Link Frequency Relevance Heat Osteogenic Sarcomas 4 100.00 Leber Hereditary Optic Atrophy 48 98.68 Wallerian Degeneration 87 96.08 Bone Cancer 10 89.36 Sarcoma 1 84.08 Ganglion Cysts 10 82.88 Pain 2 72.00 Neuroblastoma 18 66.12 Drug Induced Neurotoxicity 14 56.56 Toxicity 5 44.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).

Localization (colocalization) of NF200 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide

1) Confidence 0.32 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.17 Pain Relevance 0.63

In contrast, cleavage of NF-H was prevented, showing that proteins that degrade as a consequence of degeneration are stabilized in WldS neurites.

Localization (cleavage) of NF-H in neurites associated with wallerian degeneration

2) Confidence 0.18 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.68 Pain Relevance 0

Phosphorylated NF-H is localized in mature axons, but not in dendrites.

Localization (localized) of NF-H in dendrites

3) Confidence 0.10 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0

cells bore spontaneous neurites exhibiting axon-like properties with the localization of NF-H.

Localization (localization) of NF-H in neurites

4) Confidence 0.10 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.12 Pain Relevance 0.08

Elevated pNF-H released into the serum of some affected LHON patients may suggest that axonal degeneration occurs at some point after loss of visual function.

Localization (released) of pNF-H associated with leber hereditary optic atrophy

5) Confidence 0.09 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2605731 Disease Relevance 0.25 Pain Relevance 0

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