INT145514

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.23
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
neurites 2
dendrites 1
IB4 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3 100.00 Very High Very High Very High
Cancer pain 6 88.96 High High
Neurotransmitter 10 83.64 Quite High
Root ganglion neuron 1 75.00 Quite High
Pain 4 72.00 Quite High
antagonist 1 60.72 Quite High
Analgesic 1 57.56 Quite High
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
dorsal root ganglion 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 4 100.00 Very High Very High Very High
Leber Hereditary Optic Atrophy 48 98.68 Very High Very High Very High
Wallerian Degeneration 87 96.08 Very High Very High Very High
Bone Cancer 10 89.36 High High
Sarcoma 1 84.08 Quite High
Ganglion Cysts 10 82.88 Quite High
Pain 2 72.00 Quite High
Neuroblastoma 18 66.12 Quite High
Drug Induced Neurotoxicity 14 56.56 Quite High
Toxicity 5 44.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).
Localization (colocalization) of NF200 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide
1) Confidence 0.32 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.17 Pain Relevance 0.63
In contrast, cleavage of NF-H was prevented, showing that proteins that degrade as a consequence of degeneration are stabilized in WldS neurites.
Localization (cleavage) of NF-H in neurites associated with wallerian degeneration
2) Confidence 0.18 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.68 Pain Relevance 0
Phosphorylated NF-H is localized in mature axons, but not in dendrites.
Localization (localized) of NF-H in dendrites
3) Confidence 0.10 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
cells bore spontaneous neurites exhibiting axon-like properties with the localization of NF-H.
Localization (localization) of NF-H in neurites
4) Confidence 0.10 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.12 Pain Relevance 0.08
Elevated pNF-H released into the serum of some affected LHON patients may suggest that axonal degeneration occurs at some point after loss of visual function.
Localization (released) of pNF-H associated with leber hereditary optic atrophy
5) Confidence 0.09 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2605731 Disease Relevance 0.25 Pain Relevance 0

General Comments

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