INT145515

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 10.12
Pain Relevance 12.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 8
IB4 6
blood 4
plasma 4
amygdala 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 588 100.00 Very High Very High Very High
substance P 74 100.00 Very High Very High Very High
Calcitonin gene-related peptide 64 100.00 Very High Very High Very High
calcitonin gene related peptide 56 100.00 Very High Very High Very High
Inflammation 215 99.98 Very High Very High Very High
bradykinin 48 99.48 Very High Very High Very High
Morphine 57 99.44 Very High Very High Very High
amygdala 126 98.24 Very High Very High Very High
opioid receptor 110 97.72 Very High Very High Very High
dorsal root ganglion 41 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 16 100.00 Very High Very High Very High
INFLAMMATION 228 99.98 Very High Very High Very High
Injury 37 99.98 Very High Very High Very High
Nociception 192 99.04 Very High Very High Very High
Hypersensitivity 17 98.76 Very High Very High Very High
Ganglion Cysts 67 97.52 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 97.48 Very High Very High Very High
Dyspepsia 3 95.84 Very High Very High Very High
Bone Cancer 34 93.04 High High
Pain 247 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
Positive_regulation (abundance) of in rectum Localization (Localization) of TRPV1 in large intestine associated with qutenza
1) Confidence 0.50 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 19497956 Disease Relevance 0 Pain Relevance 0.41
Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).
Positive_regulation (increased) of Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide
2) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.17 Pain Relevance 0.63
Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).
Positive_regulation (increased) of Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide
3) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.18 Pain Relevance 0.64
Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).
Positive_regulation (increased) of Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide
4) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.16 Pain Relevance 0.62
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (increased) of Localization (translocation) of TRPV1
5) Confidence 0.50 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
Moreover, the capsaicin-induced desensitization of TRPV1 was markedly attenuated in the presence of propofol in neurons from wild-type mice but not in neurons from PKCepsilon-null mice.
Positive_regulation (induced) of Localization (desensitization) of TRPV1 in neurons
6) Confidence 0.50 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.07 Pain Relevance 0
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (stimulated) of Localization (translocation) of TRPV1
7) Confidence 0.50 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
TRPV1 mediated CGRP release could play a role in increasing blood supply to malignancies of the GI tract; the beneficial effect of COX inhibitors in this regard may arise from their ability to reduce TRPV1-mediated CGRP release and inhibition of PG-mediated angiogenesis.
Positive_regulation (mediated) of Localization (release) of TRPV1 in blood associated with calcitonin gene related peptide
8) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.61 Pain Relevance 0.88
Of concern are the maintenance of body temperature, TRPV1-mediated SP and CGRP release and their subsequent effect on the cardiovascular functions and acute nociception.
Positive_regulation (mediated) of Localization (release) of TRPV1 in body associated with nociception, calcitonin gene related peptide and substance p
9) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.72 Pain Relevance 0.89
TRPV1 mediated CGRP release could play a role in increasing blood supply to malignancies of the GI tract; the beneficial effect of COX inhibitors in this regard may arise from their ability to reduce TRPV1-mediated CGRP release and inhibition of PG-mediated angiogenesis.
Positive_regulation (mediated) of Localization (release) of TRPV1 in blood associated with calcitonin gene related peptide
10) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.49 Pain Relevance 0.99
Phosphorylation not only sensitizes the receptor and augments its response, but also promotes translocation of TRPV1 from the cytosol to the plasma membrane [124, 167, 190].
Positive_regulation (promotes) of Localization (translocation) of TRPV1 in plasma
11) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.29 Pain Relevance 0.45
The transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1), which are expressed in the nociceptive neurons, induce a sensation of heat on activation by some pungent ingredients in food.
Positive_regulation (potential) of Localization (potential) of vanilloid 1 in neurons associated with nociception
12) Confidence 0.50 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.10 Pain Relevance 0.04
The transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1), which are expressed in the nociceptive neurons, induce a sensation of heat on activation by some pungent ingredients in food.
Positive_regulation (potential) of Localization (potential) of TRPV1 in neurons associated with nociception
13) Confidence 0.50 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.10 Pain Relevance 0.04
It can be suggested that sensitization of TRPV1 by endovanilloids might induce a strong impact on brain plasticity in the amygdala due to an overexcitation.
Spec (might) Positive_regulation (induce) of Localization (sensitization) of TRPV1 in amygdala associated with amygdala
14) Confidence 0.49 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.20 Pain Relevance 0.70
These data clearly show that TRPV1 currents evoked by any of three different stimuli (capsaicin, proton, or heat) are potentiated or sensitized by PGE2 through EP1 receptor activation.
Positive_regulation (activation) of Localization (potentiated) of TRPV1 associated with qutenza
15) Confidence 0.49 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.31
A step increase of temperature from 22 to 40 degrees C caused a TRPV1-independent CGRP release that was doubled by bradykinin in wild-types but not TRPV1(-/-).
Positive_regulation (caused) of Localization (release) of TRPV1 associated with bradykinin and calcitonin gene-related peptide
16) Confidence 0.47 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19473241 Disease Relevance 0.45 Pain Relevance 0.68
Co-localization of TDAG8 with TRPV1 increased after inflammation
Positive_regulation (increased) of Localization (localization) of TRPV1 associated with inflammation
17) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.36 Pain Relevance 0.31
We propose that GRK6 regulates inflammation-induced sensitization of TRPV1.
Positive_regulation (induced) of Localization (sensitization) of TRPV1 associated with inflammation
18) Confidence 0.45 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 18687398 Disease Relevance 1.17 Pain Relevance 1.28
We examined whether morphine can inhibit TRPV1-mediated increases in intracellular free Ca2+ under basal conditions and with prior sensitization of TRPV1.
Positive_regulation (increases) of Localization (sensitization) of TRPV1 associated with morphine
19) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0 Pain Relevance 1.13
Furthermore, phosphorylation also promotes translocation of TRPV1 from the cytosol to the plasma membrane [22,23].
Positive_regulation (promotes) of Localization (translocation) of TRPV1 in plasma
20) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.27 Pain Relevance 0.51

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