INT145520

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 14.04
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 3
colon 2
lymphocytes 1
immune system 1
thickening 1
Dss1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 452 99.90 Very High Very High Very High
withdrawal 36 98.44 Very High Very High Very High
Lasting pain 14 98.10 Very High Very High Very High
Opioid 61 97.60 Very High Very High Very High
Spinal cord 4 97.04 Very High Very High Very High
qutenza 6 92.92 High High
Visceral pain 4 84.36 Quite High
cytokine 151 81.84 Quite High
Crohn's disease 39 78.28 Quite High
behavioral therapy 1 77.28 Quite High
Disease Link Frequency Relevance Heat
Colitis 331 100.00 Very High Very High Very High
Neuropathic Pain 14 100.00 Very High Very High Very High
Syndrome 10 100.00 Very High Very High Very High
Pressure And Volume Under Development 11 99.98 Very High Very High Very High
INFLAMMATION 444 99.90 Very High Very High Very High
Urological Neuroanatomy 36 99.84 Very High Very High Very High
Targeted Disruption 14 99.26 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.24 Very High Very High Very High
Cancer 44 99.04 Very High Very High Very High
Inflammatory Bowel Disease 309 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DSS colitis was induced by adding 1% of DSS to the drinking water.
Positive_regulation (induced) of DSS associated with colitis
1) Confidence 0.39 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656446 Disease Relevance 0.79 Pain Relevance 0.83
Fig. 5B show high amounts of DSS at 12 h, 36 h and 120 h, but low levels at 18 h and 24 h.
Positive_regulation (amounts) of DSS
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0 Pain Relevance 0
This might give a faster and more direct access of the DSS to the epithelial cells, thus exposing these for higher concentrations of DSS.
Positive_regulation (access) of DSS in epithelial cells
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.40 Pain Relevance 0.12
This might give a faster and more direct access of the DSS to the epithelial cells, thus exposing these for higher concentrations of DSS.
Positive_regulation (concentrations) of DSS in epithelial cells
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.40 Pain Relevance 0.12
Collaboration on an iterative design process between the ATHENA-OT developers, local content experts, and the authors of the CPG for management of opioid therapy for chronic pain identified issues that arise in encoding a DSS and provided a mechanism for their resolution, resulting in an automated DSS that fulfils the intentions of the CPG authors.
Positive_regulation (resulting) of DSS associated with lasting pain and opioid
5) Confidence 0.33 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.34 Pain Relevance 0.59
The guanidinium chlorides soluble fraction contained the DSS that had accumulated in the distal colon in addition to some Muc2 (marked M).
Positive_regulation (accumulated) of DSS in colon
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0 Pain Relevance 0
We found that DSS-induced increases of MPO activity reached to the maximum level of 92±28 mUnits/ug protein at day-5 group, 6-fold higher than that of the controls (14±3.5 mUnits/ug).
Positive_regulation (increases) of DSS associated with urological neuroanatomy
7) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.92 Pain Relevance 0.19
Submucosal edema increased during DSS treatment 1-, 3-, 5-day group (Fig. 3) and recovered to normal state at day 9 and day 14 (Fig. 3); Infiltration of immune cells including neutrophils and lymphocytes were seen in the lamina propria in DSS treated mice (Fig. 3 1-, 3-, 5-day), and cleared after the DSS withdrawal in 9- and 14-day group.


Positive_regulation (increased) of DSS in lymphocytes associated with pressure and volume under development and withdrawal
8) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.77 Pain Relevance 0.25
This demonstrates that the concomitant application of EcN during colitis induction with DSS markedly ameliorates the leakiness of the colonic epithelium.


Positive_regulation (induction) of DSS in epithelium associated with colitis
9) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.24 Pain Relevance 0
Although the involvement of TLR in the stimulation of the immune system by the bacterial components is well documented, their implication in inflammatory diseases remains confusing: they were also shown to be essential to maintain a mucosal homeostasis during intestinal inflammation, as observed with MyD88-/- knockout mice which are very sensible to the induction of DSS colitis [5].
Positive_regulation (induction) of DSS in immune system associated with colitis, targeted disruption, inflammation and disease
10) Confidence 0.09 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 1.33 Pain Relevance 0.39
The macroscopic score (mucosal thickening, hyperaemia, ulcerations) was also significantly increased in DSS-treated group (Figure 2A).
Positive_regulation (increased) of DSS in thickening associated with increased venous pressure under development
11) Confidence 0.06 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 1.19 Pain Relevance 0.19
After acclimatization, colonic inflammation was induced by the addition of 1% (w/v) DSS (40 kDa; ICN n°160110) in drinking water for 10 days (group B/C/D; DSS+) until their sacrifice for digestive tissue collection.
Positive_regulation (induced) of DSS associated with inflammation
12) Confidence 0.06 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.36 Pain Relevance 0.09
Submucosal edema increased during DSS treatment 1-, 3-, 5-day group (Fig. 3) and recovered to normal state at day 9 and day 14 (Fig. 3); Infiltration of immune cells including neutrophils and lymphocytes were seen in the lamina propria in DSS treated mice (Fig. 3 1-, 3-, 5-day), and cleared after the DSS withdrawal in 9- and 14-day group.


Positive_regulation (increased) of DSS in neutrophils associated with pressure and volume under development and withdrawal
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.77 Pain Relevance 0.25
The colitis was chemically induced with DSS and clinical signs comparable to those of human ulcerative colitis [32] were observed such as body weight loss, diarrhea, bloody stool, mucosal ulceration, and shortening of colon length [33].
Positive_regulation (induced) of DSS in colon associated with colitis, inflammatory bowel disease, diarrhoea and body weight
14) Confidence 0.02 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.75 Pain Relevance 0.04
In addition, the DSS-induced model recreates some important immunological and histopathological aspects of IBD occurring in humans.
Positive_regulation (induced) of DSS associated with inflammatory bowel disease
15) Confidence 0.02 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 1.07 Pain Relevance 0.17
Clinically missense mutations in the MPZ gene can cause congenital hypomyelinating neuropathy (CH), DSS, CMT type 1, CMT type 2 and intermediate CMT [6,16-22].
Positive_regulation (cause) of DSS associated with syndrome and neuropathic pain
16) Confidence 0.02 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.98 Pain Relevance 0
After induction of the DSS-AOM model of carcinogenesis (i.e. after 100 days), colonic adenomas as well as normal colonic mucosa were analyzed by immunostaining for different antigens known to be associated with the colitis dysplasia-carcinoma sequence.
Positive_regulation (induction) of DSS-AOM associated with colitis, adenoma, cleidocranial dysplasia and carcinoma
17) Confidence 0.01 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 1.32 Pain Relevance 0.04
The DSS-AOM model of carcinogenesis was induced in female inbred C57BL/6 mice (Charles River, Sulzfeld, Germany, body weight 22-25g) which were randomized into two groups with n = 9 animals each.
Positive_regulation (induced) of DSS-AOM in body associated with body weight
18) Confidence 0.01 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 1.17 Pain Relevance 0.03
The DSS-AOM model of carcinogenesis was induced in female inbred C57BL/6 mice.
Positive_regulation (induced) of DSS-AOM
19) Confidence 0.01 Published 2010 Journal Journal of Carcinogenesis Section Abstract Doc Link PMC2862504 Disease Relevance 0.98 Pain Relevance 0.08

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