INT145528

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Context Info
Confidence 0.28
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.47
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
blood 2
plasma 2
liver 2
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 41 100.00 Very High Very High Very High
agonist 4 30.00 Quite Low
Inflammation 26 21.12 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Hepatotoxicity 8 97.94 Very High Very High Very High
Multiple Organ Failure 36 96.24 Very High Very High Very High
Injury 23 88.36 High High
Toxicity 9 86.32 High High
Hypoxia 2 86.08 High High
Apoptosis 18 86.00 High High
Death 8 78.56 Quite High
Overdose 3 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no additional reduction in plasma levels of AST and ALT was observed when sodium sulphate was co-administered with NAC.
Neg (no) Negative_regulation (reduction) of Gene_expression (levels) of AST in plasma
1) Confidence 0.28 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.15 Pain Relevance 0.72
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Negative_regulation (blocked) of Gene_expression (depletion) of AST associated with paracetamol and hepatotoxicity
2) Confidence 0.23 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.67 Pain Relevance 0.99
Mice were sacrificed 12 h after the APAP injection to determine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation, and caspase-3 expression in liver tissues.
Spec (determine) Negative_regulation (determine) of Gene_expression (levels) of AST in liver associated with necrosis, paracetamol and cancer
3) Confidence 0.23 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.65 Pain Relevance 0.85
Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity.
Negative_regulation (reduced) of Gene_expression (levels) of AST associated with paracetamol
4) Confidence 0.22 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838823 Disease Relevance 0.31 Pain Relevance 0.64
To further confirm these data, we found that GW0742 treatment not only prevents lung dysfunction, and reduces zymosan-induced loss of blood PaO2, PCO2, HCO3- and pH levels, but also diminishes other blood parameters, such as the levels of AST, ALT, bilirubin and alkaline phosphatase that are altered after the onset of zymosan-induced MOF.
Negative_regulation (diminishes) of Gene_expression (levels) of AST in blood associated with multiple organ failure
5) Confidence 0.12 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.69 Pain Relevance 0

General Comments

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