INT145530

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK1) nucleus (KLK1)
KLK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 20 98.36 Very High Very High Very High
Analgesic 1 97.76 Very High Very High Very High
cINOD 1 96.24 Very High Very High Very High
antagonist 6 95.96 Very High Very High Very High
Inflammation 6 91.96 High High
Pain 5 50.64 Quite High
Pain score 1 9.32 Low Low
vincristine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 96.04 Very High Very High Very High
Arthropathy 1 85.56 High High
Hereditary Angioedema 64 73.84 Quite High
Disease 5 65.68 Quite High
Pressure And Volume Under Development 31 59.20 Quite High
Injury 2 56.28 Quite High
Infection 1 55.96 Quite High
Laryngeal Edema 2 39.36 Quite Low
Emergencies 1 18.00 Low Low
Unconsciousness 1 14.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the contact system pathway, C1-inhibitor inactivates both factor XIIa and active kallikrein, thereby preventing both the activation of kallikrein from prekallikrein and the formation of bradykinin, a vascular permeability factor [2,20,21,23-25].
Negative_regulation (preventing) of Positive_regulation (activation) of kallikrein associated with bradykinin
1) Confidence 0.42 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.50 Pain Relevance 0.15
Furthermore, it is suggested that substances to reduce activation of the kallikrein-kinin system (KKS) may provide a pharmacological basis for the synthesis of novel antirheumatic or anti-inflammatory drugs.
Negative_regulation (reduce) of Positive_regulation (activation) of kallikrein-kinin associated with inflammation and cinod
2) Confidence 0.02 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657626 Disease Relevance 0.52 Pain Relevance 0.41

General Comments

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