INT145538

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
IER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
bioavailability 2 93.64 High High
depression 53 90.84 High High
Withdrawal 22 81.44 Quite High
Antidepressant 9 57.16 Quite High
monoamine 3 49.24 Quite Low
dopamine 4 33.76 Quite Low
Noradrenaline 2 33.04 Quite Low
pain 3 25.00 Low Low
dopamine receptor 1 19.04 Low Low
Serotonin 4 12.68 Low Low
Disease Link Frequency Relevance Heat
Depression 98 98.10 Very High Very High Very High
Panic Disorder 67 23.12 Low Low
Anxiety Disorder 43 5.00 Very Low Very Low Very Low
Phobia 17 5.00 Very Low Very Low Very Low
Agoraphobia 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 6 5.00 Very Low Very Low Very Low
Recurrence 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, while some depressive behaviour may be advantageous for the depressed individual, and is therefore “adaptive” in an immediate sense, it cannot be accurately described as “evolutionary”.
Localization (sense) of immediate associated with depression
1) Confidence 0.12 Published 2010 Journal Depression Research and Treatment Section Abstract Doc Link PMC2989690 Disease Relevance 0.50 Pain Relevance 0.16
OBJECTIVE: To review the pharmacodynamics, pharmacokinetics, efficacy, tolerability, dosing, and role of oral oxymorphone immediate-release (IR) and extended-release (ER).
Localization (release) of immediate-release
2) Confidence 0.10 Published 2007 Journal Consult Pharm Section Abstract Doc Link 17658959 Disease Relevance 0 Pain Relevance 0
When equal daily doses of venlafaxine are administered, as immediate-release or the extended-release, exposure to both venlafaxine and ODV is similar and the fluctuation in plasma concentrations is slightly lower with the venlafaxine XR capsule.
Localization (release) of immediate-release in plasma
3) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654536 Disease Relevance 0 Pain Relevance 0.12

General Comments

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