INT145545

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.48
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
Catecholamine 12 100.00 Very High Very High Very High
Pain 4 87.96 High High
Opioid 4 75.00 Quite High
Ventral tegmentum 8 72.16 Quite High
Nucleus accumbens 2 59.20 Quite High
agonist 4 50.00 Quite Low
Somatostatin 4 50.00 Quite Low
midbrain 4 25.00 Low Low
opiate 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Opiate Addiction 8 94.12 High High
Tendinopathy 8 89.76 High High
Pain 4 87.96 High High
Congenital Anomalies 2 75.00 Quite High
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A ssDNA probe detecting human mRNA for the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) was applied.
Transcription (detecting) of TH associated with catecholamine
1) Confidence 0.67 Published 2007 Journal Microsc. Res. Tech. Section Abstract Doc Link 17661370 Disease Relevance 0.49 Pain Relevance 0.41
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
Transcription (detect) of TH
2) Confidence 0.67 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
A ssDNA probe detecting human mRNA for the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) was applied.
Transcription (detecting) of catecholamine-synthesizing enzyme tyrosine hydroxylase associated with catecholamine
3) Confidence 0.60 Published 2007 Journal Microsc. Res. Tech. Section Abstract Doc Link 17661370 Disease Relevance 0.49 Pain Relevance 0.41
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Transcription (levels) of TH associated with dopamine and opiate addiction
4) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Transcription (levels) of tyrosine hydroxylase associated with dopamine and opiate addiction
5) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
Transcription (detect) of tyrosine hydroxylase
6) Confidence 0.26 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0

General Comments

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