INT14557

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 96
Total Number 100
Disease Relevance 54.83
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 10
plasma 5
muscle 4
blood 2
skeletal muscle 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 1 99.80 Very High Very High Very High
narcan 5 99.50 Very High Very High Very High
cytokine 180 99.18 Very High Very High Very High
Inflammation 266 98.98 Very High Very High Very High
Central nervous system 76 98.84 Very High Very High Very High
Somatostatin 479 98.00 Very High Very High Very High
Hyperalgesia 2 98.00 Very High Very High Very High
Opioid 2 97.58 Very High Very High Very High
peripheral neuropathy 1 97.34 Very High Very High Very High
agonist 93 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Carcinoid 26 100.00 Very High Very High Very High
Aging 2319 99.92 Very High Very High Very High
Syndrome 726 99.92 Very High Very High Very High
Acidosis 18 99.90 Very High Very High Very High
Hypoglycemia 99 99.88 Very High Very High Very High
Lifespan 1377 99.84 Very High Very High Very High
Disease 664 99.84 Very High Very High Very High
Pulmonary Disease 196 99.84 Very High Very High Very High
Helminth Infection 29 99.78 Very High Very High Very High
Toxicity 66 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations.
Negative_regulation (reduction) of IGF-I in liver
1) Confidence 0.59 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.23 Pain Relevance 0.12
IGF-I is a neuroprotective hormone, and neurodegenerative disorders, including Alzheimer's disease, have been associated with decreased serum IGF-I concentration.
Negative_regulation (decreased) of IGF-I associated with disease and neurodegenerative disease
2) Confidence 0.59 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.20 Pain Relevance 0
The decline in serum IGF-I with increasing age may therefore be important for the age-related decline in memory function.
Negative_regulation (decline) of IGF-I
3) Confidence 0.59 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.21 Pain Relevance 0.22
The induction pattern of Snm1 is opposite that of IGF-I across contrasts, such that its expression is increased in proportion to IGF-I inhibition.
Negative_regulation (inhibition) of IGF-I
4) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.45 Pain Relevance 0
It is interesting to note, moreover, that IGF-I transcript levels are significantly downregulated with respect to the GHR-KI2 contrast, but not with respect to the GHR-KI1 contrast (Fig. 1, Table 2).
Negative_regulation (downregulated) of IGF-I
5) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
IGF-I was significantly downregulated in all contrasts involving dwarf mutants, but only one of four CR treatments resulted in significant IGF-I downregulation [contrast cr(2,6)df].
Negative_regulation (downregulation) of IGF-I
6) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
IGF-I was significantly downregulated in all contrasts involving dwarf mutants, but only one of four CR treatments resulted in significant IGF-I downregulation [contrast cr(2,6)df].
Negative_regulation (downregulated) of IGF-I
7) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
GHR-KI2 mice, however, lack GHR residue 391 and have no STAT5 signaling capacity, resulting in substantial loss of IGF-1 transcript in liver [26].
Negative_regulation (loss) of IGF-1 in liver
8) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Postnatal growth deficiency and reduced IGF-I
Negative_regulation (reduced) of IGF-I
9) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.05 Pain Relevance 0
In this study there was a parallel decrease in GH and IGF-I and in left ventricular mass index; these data were confirmed in another study (Baldelli et al 1999; Hradec et al 1999).
Negative_regulation (decrease) of IGF-I
10) Confidence 0.55 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.63 Pain Relevance 0
effectively reduced free IGF-1 levels and activity, and promoted endothelial instability.
Negative_regulation (reduced) of IGF-1
11) Confidence 0.53 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.54 Pain Relevance 0.11
IGF-1 mRNA from liver, the major source of circulating IGF-1, was significantly reduced in both (Figure 4C, p < 0.05).
Negative_regulation (reduced) of IGF-1 mRNA in liver
12) Confidence 0.52 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.77 Pain Relevance 0
Compared to normally sized XPA animals, serum IGF-1 was reduced in both XPCS/XPA and CH/XPA pups, although only to a level of statistical significance in XPCS/XPA animals (p < 0.05).
Negative_regulation (reduced) of IGF-1
13) Confidence 0.52 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.72 Pain Relevance 0
In a number of model organisms including worms and mice, suppression of the GH/IGF-1 axis is associated with increased stress resistance and extended longevity [31].
Negative_regulation (suppression) of IGF-1 associated with stress, helminth infection and aging
14) Confidence 0.52 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.72 Pain Relevance 0
created by Holzenberger and co-workers (2003) have a 50% reduction in IGF-1 receptors in several tissues and hence reduced signaling through this pathway.
Negative_regulation (reduction) of IGF-1
15) Confidence 0.50 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.79 Pain Relevance 0
Thus, on the level of gene expression, downregulation of the somatotropic GH/IGF-1 axis correlated with the severity of NER progeria.
Negative_regulation (downregulation) of somatotropic GH/IGF-1 associated with hutchinson-gilford progeria syndrome
16) Confidence 0.45 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.32 Pain Relevance 0
Peripheral neuropathy is a particularly debilitating complication of both type 1 and type 2 diabetes characterized by sensory and motor neuron damage and decreased circulating levels of insulin-like growth factor 1 (IGF-1).
Negative_regulation (decreased) of IGF-1 in motor neuron associated with diabetes mellitus and peripheral neuropathy
17) Confidence 0.43 Published 2008 Journal Mol. Ther. Section Abstract Doc Link 18545223 Disease Relevance 0.96 Pain Relevance 0.61
To determine whether the observed hypothalamic inhibition of endocrine GH and IGF-I was specific, we assessed gonado- and thyrotropic functions in mutant animals by monitoring fertility, reproduction, and energy metabolism. bIGF1RKO+/?
Negative_regulation (inhibition) of IGF-I
18) Confidence 0.42 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.03
Both genetic and nutritional intervention led to growth deficits and a lifelong reduction in endocrine IGF-I.
Negative_regulation (reduction) of IGF-I
19) Confidence 0.42 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.18 Pain Relevance 0.04
It is therefore surprising that in long-lived and CR mice, IGF-I inhibition is associated with elevated Snm1 expression, which may enhance DNA repair and promote genomic stability.
Negative_regulation (inhibition) of IGF-I associated with genomic instability
20) Confidence 0.42 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.49 Pain Relevance 0

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