INT14559

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 254
Total Number 262
Disease Relevance 112.00
Pain Relevance 34.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 18
sensory neurons 16
plasma 11
skin 10
hair 8
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 467 100.00 Very High Very High Very High
Calcitonin gene-related peptide 276 100.00 Very High Very High Very High
chemokine 68 100.00 Very High Very High Very High
Somatostatin 1204 99.92 Very High Very High Very High
qutenza 263 99.78 Very High Very High Very High
Hippocampus 139 99.68 Very High Very High Very High
Inflammation 528 99.54 Very High Very High Very High
Osteoarthritis 26 99.54 Very High Very High Very High
opiate 2 99.24 Very High Very High Very High
Central nervous system 252 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lifespan 1974 100.00 Very High Very High Very High
Stress 738 100.00 Very High Very High Very High
Frailty 367 100.00 Very High Very High Very High
Hypoxia 86 100.00 Very High Very High Very High
Osteoporosis 66 100.00 Very High Very High Very High
Chronic Renal Failure 34 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 58 99.98 Very High Very High Very High
Injury 818 99.96 Very High Very High Very High
Pathologic Neovascularization 7 99.92 Very High Very High Very High
Hematological Disease 24 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations.
Gene_expression (production) of IGF-I in liver
1) Confidence 0.78 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.19 Pain Relevance 0.08
These observations raise the possibility that administration of capsaicin and isoflavone might promote hair growth by increasing IGF-I production.
Gene_expression (production) of IGF-I in hair associated with qutenza and alopecia
2) Confidence 0.78 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.33 Pain Relevance 0.43
Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.
Gene_expression (production) of IGF-I in sensory neurons associated with calcitonin gene-related peptide
3) Confidence 0.78 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.24 Pain Relevance 0.45
Dermal levels of IGF-I were significantly higher in WT mice administered capsaicin and isoflavone for 4 wks than in those administered capsaicin alone for 4 wks (p < 0.01) and in those administered neither of them (p < 0.01).
Gene_expression (levels) of IGF-I
4) Confidence 0.78 Published 2007 Journal Growth Horm. IGF Res. Section Body Doc Link 17569567 Disease Relevance 0.15 Pain Relevance 0
DESIGN: Dermal IGF-I levels, immunohistochemical expression of IGF-I in the skin and hair regrowth were examined after capsaicin and isoflavone administration to wild-type (WT) mice and CGRP-knockout mice.
Spec (examined) Gene_expression (expression) of IGF-I in hair
5) Confidence 0.78 Published 2007 Journal Growth Horm. IGF Res. Section Body Doc Link 17569567 Disease Relevance 0.19 Pain Relevance 0
Increased neural activity in transgenic mice with brain IGF-I overexpression: a [3H]2DG study.
Gene_expression (overexpression) of IGF-I in brain associated with targeted disruption
6) Confidence 0.77 Published 1997 Journal Neuroreport Section Title Doc Link 9376529 Disease Relevance 0.52 Pain Relevance 0.08
To evaluate whether insulin-like growth factor-I (IGF-I) modulates neural activity in vivo, relative levels of brain [3H]2-deoxyglucose (2DG) uptake were compared in adult behaving and anesthetized wild type (wt) mice, and transgenic (Tg) mice with either brain IGF-I overexpression or ectopic brain expression of IGF binding protein-1 (IGFBP-1).
Gene_expression (overexpression) of IGF-I in neural associated with targeted disruption
7) Confidence 0.77 Published 1997 Journal Neuroreport Section Abstract Doc Link 9376529 Disease Relevance 0.53 Pain Relevance 0.08
These observations suggested that capsaicin-induced sensory neuron activation, which leads to release of CGRP, might increase IGF-I production, thereby reducing reperfusion-induced liver injury by reducing apoptosis.
Gene_expression (production) of IGF-I in liver associated with qutenza, injury, apoptosis and calcitonin gene-related peptide
8) Confidence 0.77 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.70 Pain Relevance 0.78
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
Gene_expression (production) of insulin-like growth factor-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
9) Confidence 0.77 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
Gene_expression (production) of IGF-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
10) Confidence 0.77 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
Gene_expression (production) of IGF-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
11) Confidence 0.77 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.45 Pain Relevance 0.52
We examined whether stimulation of sensory neurons by capsaicin might reduce reperfusion-induced hepatic apoptosis by increasing IGF-I production.
Gene_expression (production) of IGF-I in sensory neurons associated with qutenza and apoptosis
12) Confidence 0.77 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.50 Pain Relevance 0.67
In this study, we examined whether topical application of alpha-D-glucosylglycerol (GG), a compound found in Japanese traditional brewed foods such as sake (Japanese rice wine), increases the dermal production of IGF-I in mice and increases the facial skin elasticity in females.
Gene_expression (production) of IGF-I in skin
13) Confidence 0.77 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.31 Pain Relevance 0.21
We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans.
Gene_expression (production) of IGF-I in sensory neurons associated with qutenza
14) Confidence 0.77 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.14 Pain Relevance 0.17
These observations strongly suggest that GG increases the production of IGF-I in the skin through sensory neuron stimulation, thereby increasing skin elasticity.
Gene_expression (production) of IGF-I in sensory neuron
15) Confidence 0.77 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.34 Pain Relevance 0.18
These observations strongly suggest that the stimulation of sensory neurons by capsaicin might increase IGF-I production via increasing the hippocampal tissue CGRP levels, and it may thereby promote angiogenesis and neurogenesis to produce improvement of the cognitive function in mice.
Gene_expression (production) of IGF-I in sensory neurons associated with cognitive disorder, qutenza, neurodegenerative disease and calcitonin gene-related peptide
16) Confidence 0.77 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.45 Pain Relevance 1.17
In the current study, we examined whether stimulation of sensory neurons by capsaicin improved the cognitive function by increasing the production of IGF-I in the hippocampus using wild-type (WT) and CGRP-knockout (CGRP-/-) mice.
Gene_expression (production) of IGF-I in sensory neurons associated with targeted disruption, cognitive disorder, qutenza, hippocampus and calcitonin gene-related peptide
17) Confidence 0.77 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.52 Pain Relevance 0.84
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
Gene_expression (production) of IGF-I in brain associated with calcitonin gene-related peptide
18) Confidence 0.77 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44
Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice.
Gene_expression (production) of insulin-like growth factor-I in sensory neurons associated with cognitive disorder and qutenza
19) Confidence 0.77 Published 2009 Journal Transl Res Section Title Doc Link 19595440 Disease Relevance 0.51 Pain Relevance 1.05
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
Gene_expression (production) of insulin-like growth factor-I in brain associated with calcitonin gene-related peptide
20) Confidence 0.77 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44

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