INT1456

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 61
Total Number 68
Disease Relevance 19.50
Pain Relevance 52.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 6
blood 3
plasma 2
neuronal 2
cardiac ventricle 1
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 199 100.00 Very High Very High Very High
Pain 165 100.00 Very High Very High Very High
narcan 120 100.00 Very High Very High Very High
agonist 102 100.00 Very High Very High Very High
orphanin 77 100.00 Very High Very High Very High
opioid receptor 66 100.00 Very High Very High Very High
Analgesic 63 100.00 Very High Very High Very High
antagonist 55 100.00 Very High Very High Very High
Kappa opioid receptor 47 100.00 Very High Very High Very High
Enkephalin 24 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 26 99.96 Very High Very High Very High
Nociception 23 99.84 Very High Very High Very High
Vibrio Infection 16 99.84 Very High Very High Very High
Post Operative Pain 8 99.72 Very High Very High Very High
Bordatella Infection 16 99.60 Very High Very High Very High
Inflammatory Pain 1 99.54 Very High Very High Very High
Hypotension 16 99.32 Very High Very High Very High
Hypothermia 11 99.28 Very High Very High Very High
Frailty 8 99.04 Very High Very High Very High
Nervous System Injury 12 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.
Regulation (modulate) of opiate receptor associated with opiate
1) Confidence 0.62 Published 1980 Journal Science Section Abstract Doc Link 6246583 Disease Relevance 0 Pain Relevance 0.80
Selective effects of ethanol on opiate receptor subtypes in brain.
Regulation (effects) of opiate receptor in brain associated with enkephalin and opiate
2) Confidence 0.62 Published 1987 Journal Neuropharmacology Section Title Doc Link 2825059 Disease Relevance 0.17 Pain Relevance 0.62
These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor.
Regulation (modulation) of opiate receptor associated with opiate
3) Confidence 0.57 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7371720 Disease Relevance 0 Pain Relevance 0.45
The present results characterize the time course and dose response of some of the currently available highly selective kappa- and mu-opiate agonists for the first time in mice and suggest that hyperglycaemia differentially affects the opiate receptor subtypes that mediate thermoregulatory events.
Regulation (affects) of opiate receptor associated with agonist and opiate
4) Confidence 0.57 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2164667 Disease Relevance 0.26 Pain Relevance 0.64
To further address this possible interaction we have used mu-, delta- and kappa-opioid receptor knockout mice to determine autoradiographically if there are any changes in the number or distribution of the ORL1 receptor, labelled with [(3)H]nociceptin, in the brains of mice deficient in each of the opioid receptors.
Regulation (changes) of ORL1 in brains associated with targeted disruption, orphanin, kappa opioid receptor and opioid receptor
5) Confidence 0.45 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.22 Pain Relevance 0.31
The influence of opiate receptor antagonists: naloxone, naltrexone and diprenorphine, and of an agonist: morphine on ethanol-induced sleep, hypothermia and motor coordination impairment was investigated.
Regulation (influence) of opiate receptor associated with hypothermia, ataxia, antagonist, agonist, narcan, opiate and morphine
6) Confidence 0.45 Published 1984 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 6098896 Disease Relevance 0.27 Pain Relevance 0.72
These lines of evidence may provide insight into the mechanisms controlling agonist/antagonist switching in the ORL1 receptor, and may also serve to help developing more potent ORL1 agonists and antagonists.
Regulation (controlling) of ORL1 associated with antagonist and agonist
7) Confidence 0.45 Published 2007 Journal J. Pept. Sci. Section Abstract Doc Link 17712865 Disease Relevance 0 Pain Relevance 0.71
It is concluded that ORL1 agonists can modulate the acquisition, expression, and reinstatement of the conditioned reinforcing effects of ethanol with no reinforcing or aversive properties of their own.
Regulation (modulate) of ORL1 associated with agonist
8) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490606 Disease Relevance 0 Pain Relevance 0.81
Prodynorphin peptides appear to regulate mostly the kappa-receptor but they are also modulators of micro- and delta-receptors.
Regulation (regulate) of kappa-receptor
9) Confidence 0.45 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614912 Disease Relevance 0.14 Pain Relevance 0.37
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.
Regulation (Effects) of nociceptin/orphanin FQ receptor associated with pain, acute pain, orphanin, agonist and morphine
10) Confidence 0.45 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18031727 Disease Relevance 0.65 Pain Relevance 1.53
Selectivity in the control of opiate receptor density in the animal and in cultured fetal brain cells.
Regulation (control) of opiate receptor in brain associated with opiate and immobilon
11) Confidence 0.45 Published 1984 Journal Neuropeptides Section Title Doc Link 6099496 Disease Relevance 0.17 Pain Relevance 1.02
Antisense probes targeting the second and third coding exons, but not the first exon, of the cloned mouse OFQ/N receptor (KOR-3) partially block OFQ/N analgesia.
Regulation (targeting) of KOR-3 associated with analgesia
12) Confidence 0.44 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9089686 Disease Relevance 0.17 Pain Relevance 0.73
When co-expressed with either the opioid-receptor-like (ORL1) receptor or one of the mu, delta, and kappa opioid receptors, by transfecting dual-expression plasmids into COS-7 cells, the full-length GAIP/RGS19 was more effective than the N-terminally truncated variant and was more selective in regulating the ORL1 receptor signaling than in regulating the mu, delta, and kappa opioid receptors, as measured by the effectiveness to increase the agonist-stimulated GTPase activity and to reverse the agonist-induced inhibition of cyclic AMP accumulation.
Regulation (regulating) of ORL1 associated with agonist, kappa opioid receptor and opioid
13) Confidence 0.44 Published 2005 Journal J. Mol. Biol. Section Abstract Doc Link 16219326 Disease Relevance 0 Pain Relevance 0.42
Role of Nociceptin/Orphanin FQ in the physiologic and pathologic control of the cerebral circulation.
Regulation (Role) of Nociceptin/Orphanin associated with orphanin
14) Confidence 0.44 Published 2002 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 12486205 Disease Relevance 0 Pain Relevance 0.58
The effect of general opiate receptor blockade (1.0mg/kg naloxone, i.v.) on regional cerebrovascular CO(2)-sensitivity was studied with radiolabeled microspheres in 10 distinct brain and spinal cord regions of the anesthetized cat.
Regulation (effect) of opiate receptor in brain associated with narcan, opiate and spinal cord
15) Confidence 0.43 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12576139 Disease Relevance 0.45 Pain Relevance 0.54
The present study examined the effects of opiate receptor antagonism on both the motivation to seek heroin and the reinforcing consequences of heroin administration.
Spec (examined) Regulation (effects) of opiate receptor associated with opiate
16) Confidence 0.42 Published 1998 Journal Exp Clin Psychopharmacol Section Abstract Doc Link 9861549 Disease Relevance 0 Pain Relevance 0.35
We examined the effects of opiate receptor blockade with naloxone on clonidine-induced changes in refractoriness of the cardiac ventricle.
Spec (examined) Regulation (effects) of opiate receptor in cardiac ventricle associated with narcan, opiate and clonidine
17) Confidence 0.42 Published 1989 Journal Life Sci. Section Abstract Doc Link 2770406 Disease Relevance 0.07 Pain Relevance 0.53
Pertussis and cholera toxins modulate kappa-opioid receptor agonists-induced hypothermia and gut inhibition.
Regulation (modulate) of kappa-opioid receptor in gut associated with hypothermia, analgesic, agonist, kappa opioid receptor and vibrio infection
18) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7796869 Disease Relevance 0.71 Pain Relevance 0.53
In contrast, cholera toxin pretreatment (48 and/or 96 h before) did not antagonize the hypothermic effect of the kappa-opioid receptor agonists.
Regulation (effect) of kappa-opioid receptor associated with agonist, kappa opioid receptor and vibrio infection
19) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7796869 Disease Relevance 0.77 Pain Relevance 0.47
However, pertussis toxin pretreatment did not affect the gastrointestinal inhibitory effect of the kappa-opioid receptor agonists.
Regulation (effect) of kappa-opioid receptor associated with bordatella infection, agonist and kappa opioid receptor
20) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7796869 Disease Relevance 0.60 Pain Relevance 0.84

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