INT14560

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 41
Total Number 43
Disease Relevance 19.59
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 3
brain 2
fat 2
skin 2
lens 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 40 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
Bioavailability 3 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
Opioid 5 98.44 Very High Very High Very High
Inflammation 29 98.16 Very High Very High Very High
antidepressant 180 97.64 Very High Very High Very High
Calcitonin gene-related peptide 3 96.92 Very High Very High Very High
Somatostatin 408 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 322 99.98 Very High Very High Very High
Aging 405 99.96 Very High Very High Very High
Hutchinson-gilford Progeria Syndrome 41 99.92 Very High Very High Very High
Targeted Disruption 173 99.64 Very High Very High Very High
Sprains And Strains 162 99.40 Very High Very High Very High
Lifespan 354 99.38 Very High Very High Very High
Stress 159 99.24 Very High Very High Very High
Arthropathy 13 99.00 Very High Very High Very High
Obesity 94 98.78 Very High Very High Very High
Lung Cancer 22 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis identified Snm1 (DNA cross-link repair 1a; also called Dclre1a) as a potential IGF-I regulated or co-regulated gene (see Fig. 2 and additional file 2).
Regulation (regulated) of IGF-I
1) Confidence 0.59 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.42 Pain Relevance 0
For all other dietary treatments, such as low fat diets and CR mimetics, IGF-I transcript levels were not significantly affected, and in fact, were slightly upregulated in most cases (Fig. 1, Table 2).
Neg (not) Regulation (affected) of IGF-I in fat
2) Confidence 0.59 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
The investigators could not demonstrate differences between octreotide and lanreotide, ie, the effects on GH, IGF-I, and insulin were all similar (Baldelli et al 2003).
Regulation (effects) of IGF-I
3) Confidence 0.58 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.45 Pain Relevance 0.07
Finally, in a study of 93 patients with acromegaly control of GH and IGF-I had a positive impact on the subscale appearance, but overall QoL was severely impaired (Matta et al 2008).


Regulation (control) of IGF-I associated with acromegaly
4) Confidence 0.58 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.38 Pain Relevance 0.10
In this regard, a polymorphism in the promoter region of the IGF-I gene was associated with low levels of IGF-I and increased risk of type-2 diabetes mellitus.[21] In addition to this, IGF-I binding proteins (IGFBPs) were not measured, which play an important role in regulating the bioavailability of IGF-I.
Regulation (regulating) of IGF-I associated with diabetes mellitus and bioavailability
5) Confidence 0.56 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.21 Pain Relevance 0.05
These results suggest that simvastatin decreases IGF-1 signaling via a regulation of the post-translational modification of IGF-1Rbeta in an HMG-CoA reductase inhibition-independent manner.
Regulation (regulation) of IGF
6) Confidence 0.44 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.06 Pain Relevance 0
Endocrine abnormalities differ to some degree among dwarf models, but presumably, lifespan extension in each model results from shared alterations that affect the GH/IGF-I pathway.
Regulation (affect) of IGF-I associated with lifespan and congenital anomalies
7) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.57 Pain Relevance 0
These genes are potentially regulated by or coregulated with the IGF-I transcript in mouse liver tissue.


Regulation (coregulated) of IGF-I in liver
8) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Since we observed a reduction in liver Igf1 mRNA expression and in circulating levels of IGF1 protein, indicative of GH deficiency, and since most individuals with PWS are GH deficient, we studied the structure and development of the pituitary gland to determine whether the GH deficiency is caused by a structural pituitary defect or a reduction in the number of GH producing cells in the anterior pituitary.
Regulation (levels) of IGF1 in anterior pituitary associated with syndrome
9) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.28 Pain Relevance 0
Lanreotide AutogelĀ® controls GH in 58% and IGF-I in 48% of patients.
Regulation (controls) of IGF-I
10) Confidence 0.43 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.06 Pain Relevance 0.31
Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice.
Regulation (Effects) of IGF-1 in extracellular matrix
11) Confidence 0.42 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.16
Moreover, the analyses of total IGF-I is very high, it is also possible that the nutritional and genetic factors influence the actual levels of circulating IGF-I.
Spec (possible) Regulation (influence) of IGF-I
12) Confidence 0.41 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.34 Pain Relevance 0.04
To determine whether IGF-1-mediated regulation of splicing was apparent at the protein level, podocytes were incubated with the pharmacological inhibitors of PKC (BIMI), and ELISA carried out on the protein extracted from the cells.
Spec (whether) Regulation (regulation) of IGF-1-mediated in podocytes
13) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Moreover, the concentration of the acid labile subunit (ALS), an important regulator of IGF-I stability and itself regulated by GH, was very low in mutants throughout postnatal life (Figure 2F).
Regulation (regulator) of IGF-I
14) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.09
The 6-month duration of self-/partner injections in this study was considered an appropriate length of time for changes in GH and IGF-1 levels to be observed if the injections were not being administered correctly.
Regulation (changes) of IGF-1
15) Confidence 0.32 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2268964 Disease Relevance 0.08 Pain Relevance 0
28% versus control mice 30%), but bIGF1RKO+/?
Regulation (control) of bIGF1RKO
16) Confidence 0.28 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 1.41 Pain Relevance 0.10
All 15 Test group patients and 14 out of 15 Control group patients maintained IGF-1 control (i.e. were in the same or an improved IGF-1 control band) at the Interim visit compared with Baseline.
Regulation (control) of IGF-1 in band
17) Confidence 0.28 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2268964 Disease Relevance 0 Pain Relevance 0
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.
Regulation (Effects) of insulin-like growth factor-i in skin associated with qutenza
18) Confidence 0.27 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 20378988 Disease Relevance 0.27 Pain Relevance 0.50
Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.
Regulation (Effect) of insulin-like growth factor-I in skin associated with qutenza
19) Confidence 0.27 Published 2007 Journal Growth Horm. IGF Res. Section Title Doc Link 17307377 Disease Relevance 0 Pain Relevance 1.03
This analysis identified Snm1 (DNA cross-link repair 1a; also called Dclre1a) as a potential IGF-I regulated or co-regulated gene (see Fig. 2 and additional file 2).
Regulation (regulated) of IGF-I
20) Confidence 0.26 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.43 Pain Relevance 0

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