INT14561

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Context Info
Confidence 0.35
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 6.27
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Anatomy Link Frequency
liver 1
fat 1
body 1
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 135 99.74 Very High Very High Very High
opiate 1 99.24 Very High Very High Very High
cytokine 263 99.12 Very High Very High Very High
narcan 5 98.94 Very High Very High Very High
Opioid 1 97.02 Very High Very High Very High
anesthesia 83 92.64 High High
Paracetamol 1 74.12 Quite High
Inflammation 10 70.56 Quite High
Angina 1 67.12 Quite High
Endogenous opioid 1 48.80 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 99.80 Very High Very High Very High
Body Weight 50 98.92 Very High Very High Very High
Obesity 11 98.76 Very High Very High Very High
Diabetes Mellitus 29 98.56 Very High Very High Very High
Polycystic Ovary Syndrome 9 98.48 Very High Very High Very High
Critical Illness 57 97.88 Very High Very High Very High
Sepsis 185 97.44 Very High Very High Very High
Hyperinsulinism 7 96.52 Very High Very High Very High
Hyperglycemia 3 95.48 Very High Very High Very High
Bronchopulmonary Dysplasia 30 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower levels of IGFBP-1 and a tendency to greater body weight in group C, may suggest an alternative explanation of the difference in insulin pattern between groups C and D.
Gene_expression (levels) of IGFBP-1 in body associated with body weight
1) Confidence 0.35 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.32 Pain Relevance 0
Insulin-like growth factor binding protein-1 (IGFBP-1), produced in the liver [11,21], is an important regulator of free IGF-1.
Gene_expression (produced) of IGFBP-1 in liver
2) Confidence 0.35 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.19 Pain Relevance 0.04
PN was associated with the lowest serum IGFBP-I levels in both the CLP and sham-operated groups.
Gene_expression (levels) of IGFBP-I
3) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.28 Pain Relevance 0.28
Hepatic IGFBP-I synthesis is stimulated by the cytokines IL-1, IL-6 and TNF?
Gene_expression (synthesis) of IGFBP-I associated with cytokine
4) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.28 Pain Relevance 0.27
Dexamethasone induces the hepatic synthesis of IGFBP-1.


Gene_expression (synthesis) of IGFBP-1 associated with dexamethasone
5) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.56 Pain Relevance 0.20
Our observations that PN was more efficacious, in comparison with EN, in influencing circulating IGF-I and IGFBP-I levels are in contrast to another rodent study comparing PN and EN in sepsis [28].
Gene_expression (levels) of IGFBP-I associated with sepsis
6) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.14
Fasting levels of IGF-1, Insulin-like growth factor binding protein-1 (IGFBP-1), insulin and P-glucose were studied prior to, and four days following, operation.
Gene_expression (levels) of IGFBP-1
7) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1779788 Disease Relevance 0.24 Pain Relevance 0.35
We suggest different phases of the interaction between dexamethasone and the IGF/IGFBP-1 axis:
Gene_expression (axis) of IGFBP-1 associated with dexamethasone
8) Confidence 0.27 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.47 Pain Relevance 0.18
Circulating levels of IGF-I and of the insulin-like growth factor binding protein-I (IGFBP-I) are exquisitely sensitive to provision of nutrients, the former being increased and the latter being suppressed by food intake [9].
Gene_expression (levels) of IGFBP-I
9) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.30 Pain Relevance 0.23
Circulating levels of IGF-I and of the insulin-like growth factor binding protein-I (IGFBP-I) are exquisitely sensitive to provision of nutrients, the former being increased and the latter being suppressed by food intake [9].
Gene_expression (levels) of insulin-like growth factor binding protein-I
10) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.30 Pain Relevance 0.23
Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes.
Gene_expression (levels) of IGFBP-1 in fat associated with diabetes mellitus
11) Confidence 0.13 Published 2010 Journal Horm Res Paediatr Section Title Doc Link 20389106 Disease Relevance 0.37 Pain Relevance 0.07
Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects.
Gene_expression (levels) of IGF binding protein 1 associated with obesity, narcan, polycystic ovary syndrome, opiate and opioid
12) Confidence 0.12 Published 1990 Journal Fertil. Steril. Section Abstract Doc Link 1697813 Disease Relevance 1.15 Pain Relevance 0.32
IGFs and IGFBPs were evaluated using commercially available radio-immunoassays (IGF-I, IGFBP-1, IGFBP-3: Fa.
Gene_expression (evaluated) of IGFBP-1
13) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.23 Pain Relevance 0.09
The associations between IGFBP-1 levels and HDL cholesterol, WHR, and BMI remained significant after adjustment for fasting insulin levels.
Gene_expression (levels) of IGFBP-1 associated with obesity and disorder of lipid metabolism
14) Confidence 0.10 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9484994 Disease Relevance 1.13 Pain Relevance 0.07

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