INT14562

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.32
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Anatomy Link Frequency
blood 1
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 1 99.80 Very High Very High Very High
narcan 5 99.50 Very High Very High Very High
dexamethasone 180 99.16 Very High Very High Very High
Opioid 1 97.58 Very High Very High Very High
anesthesia 80 94.04 High High
Paracetamol 1 90.84 High High
Endogenous opioid 1 48.80 Quite Low
Glutamate 1 40.96 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 12 99.90 Very High Very High Very High
Obesity 7 99.88 Very High Very High Very High
Hypoglycemia 5 99.26 Very High Very High Very High
Hyperglycemia 4 99.16 Very High Very High Very High
Asphyxia 2 98.74 Very High Very High Very High
Polycystic Ovary Syndrome 9 98.48 Very High Very High Very High
Cleidocranial Dysplasia 12 98.32 Very High Very High Very High
Insulin Resistance 18 97.36 Very High Very High Very High
Bronchopulmonary Dysplasia 40 96.56 Very High Very High Very High
Body Weight 19 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An infusion of amino acids in rats caused a decrease in IGFBP-1 without any changes in insulin [48].
Negative_regulation (decrease) of IGFBP-1
1) Confidence 0.26 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.07 Pain Relevance 0
A decrease in IGFBP-1 with unchanged insulin levels is known to reflect an improved hepatic insulin sensitivity [49].
Negative_regulation (decrease) of IGFBP-1
2) Confidence 0.26 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.07 Pain Relevance 0
In contrast to our data, Huysman et al found a reduction of IGFBP-1 only 2 days after the beginning of dexamethasone application in preterm infants with BPD on ventilation (Huysman et al 2003).
Negative_regulation (reduction) of IGFBP-1 associated with bronchopulmonary dysplasia and dexamethasone
3) Confidence 0.23 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.22 Pain Relevance 0.21
IGFBP-1 was reduced 1 and 2 weeks after dexamethasone and GH therapy, but 7 weeks after treatment IGFBP-1 concentrations were significantly elevated (Hammon et al 2003).
Negative_regulation (reduced) of IGFBP-1 associated with dexamethasone
4) Confidence 0.23 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.20 Pain Relevance 0.27
From earlier studies it is known that obesity, low levels of IGFBP-1 and an increased IGF-1:IGFBP-1 ratio are factors associated with insulin resistance in men and women [49,51].
Negative_regulation (levels) of IGFBP-1 associated with obesity and insulin resistance
5) Confidence 0.19 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.38 Pain Relevance 0
Growth hormone and IGFBP-1 concentrations were decreased in preterm children with bronchopulmonal dysplasia two days after the beginning of dexamethasone treatment compared to pre-dexamethasone levels (Huysman et al 2003).
Negative_regulation (decreased) of IGFBP-1 associated with cleidocranial dysplasia and dexamethasone
6) Confidence 0.17 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.40 Pain Relevance 0.32
Case 1: birth asphyxia, episodes of hypoglycemia after delivery, hyperinsulinism and reduced IGFBP1 blood concentration.
Negative_regulation (reduced) of IGFBP1 in blood associated with hypoglycemia, asphyxia and hyperinsulinism
7) Confidence 0.16 Published 2002 Journal Minerva Pediatr. Section Abstract Doc Link 12131869 Disease Relevance 0.97 Pain Relevance 0.09
The metabolic decompensation after glucocorticioid application causes hyperglycemia, reactive hyperinsulinism and eventually reduction of serum IGFBP-1.


Negative_regulation (reduction) of serum IGFBP-1 associated with hyperglycemia and hyperinsulinism
8) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.55 Pain Relevance 0.20
IGFBP-1 decreased significantly, but not differently, after the meals.
Neg (not) Negative_regulation (decreased) of IGFBP-1
9) Confidence 0.11 Published 2010 Journal Horm Res Paediatr Section Abstract Doc Link 20389106 Disease Relevance 0.30 Pain Relevance 0.09
Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects.
Negative_regulation (blockade) of IGF binding protein 1 associated with obesity, narcan, polycystic ovary syndrome, opiate and opioid
10) Confidence 0.09 Published 1990 Journal Fertil. Steril. Section Abstract Doc Link 1697813 Disease Relevance 1.15 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox