INT145634

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Trigeminal ganglion neurons 12 80.80 Quite High
Neurotransmitter 6 77.44 Quite High
Analgesic 1 76.88 Quite High
Nerve growth factor 3 75.00 Quite High
algogenic 1 74.56 Quite High
Calcitonin gene-related peptide 6 73.16 Quite High
Migraine 38 70.60 Quite High
Pain 38 68.72 Quite High
agonist 20 5.00 Very Low Very Low Very Low
depression 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 80.48 Quite High
Nociception 9 78.56 Quite High
Headache 8 70.60 Quite High
Pain 40 68.72 Quite High
Migraine With Aura 10 50.00 Quite Low
Migraine Disorders 26 5.00 Very Low Very Low Very Low
Depression 14 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 5A,B shows that P2X3 receptor serine-phosphorylation was significantly reduced in extracts of trigeminal cultures (n = 5, p = 0.02) from KI compared with WT.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of P2X3
1) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
NGF neutralization was associated with decreased threonine phosphorylation of P2X3 subunits, presumably accounting for their reduced responses and slower recovery.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of P2X3
2) Confidence 0.44 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17670966 Disease Relevance 0.52 Pain Relevance 0.57
The observation of decreased P2X3 receptor serine phosphorylation in KI neurons (see Fig. 5A) prompted us to consider the potential role of phosphatases contributing to this effect.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of P2X3 in neurons
3) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.04

General Comments

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