INT145635

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 22
Disease Relevance 2.74
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 9
neuronal 3
ganglia 2
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 380 99.16 Very High Very High Very High
Neurotransmitter 63 96.40 Very High Very High Very High
Migraine 380 84.08 Quite High
headache 147 83.36 Quite High
depression 147 82.00 Quite High
imagery 84 80.44 Quite High
Trigeminal ganglion neurons 107 80.00 Quite High
Analgesic 1 76.08 Quite High
Nerve growth factor 22 75.00 Quite High
algogenic 1 73.76 Quite High
Disease Link Frequency Relevance Heat
Pain 401 99.16 Very High Very High Very High
Nociception 66 97.56 Very High Very High Very High
Migraine Disorders 273 84.08 Quite High
Ganglion Cysts 233 82.00 Quite High
Depression 147 82.00 Quite High
Disease 21 77.36 Quite High
Migraine With Aura 105 75.00 Quite High
Headache 65 69.80 Quite High
Epilepsy 63 5.00 Very Low Very Low Very Low
Targeted Disruption 63 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies will be necessary to clarify this complex scenario in which multiple pathways control the phosphorylation state of P2X3 receptors with important and differential outcomes in terms of function and thus, presumably, in terms of pain sensing efficiency.


Phosphorylation (phosphorylation) of P2X3 associated with pain
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.31 Pain Relevance 0.32
Fig. 5A,B shows that P2X3 receptor serine-phosphorylation was significantly reduced in extracts of trigeminal cultures (n = 5, p = 0.02) from KI compared with WT.
Phosphorylation (phosphorylation) of P2X3
2) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
However, calcineurin inhibition enhanced P2X3 receptor threonine phosphorylation, a process that was previously associated with PKC-dependent potentiation of P2X3 receptor function especially after stimulation with NGF [9].
Phosphorylation (phosphorylation) of P2X3
3) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.26 Pain Relevance 0.20
The observation of strong CaMKII activation in KI neurons led us to examine the phosphorylation state of their P2X3 receptors.
Spec (examine) Phosphorylation (phosphorylation) of P2X3 in neurons
4) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Notwithstanding this issue, the dissimilar level of P2X3 receptor serine-phosphorylation was also found between KI and WT ganglia (n = 3, p = 0.04; data not shown).
Phosphorylation (phosphorylation) of P2X3 in ganglia
5) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
-agatoxin (200 nM, 24 h), P2X3 serine phosphorylation was significantly (p = 0.027) increased in KI neurons (n = 3; Fig. 5A).
Phosphorylation (phosphorylation) of P2X3 in neurons
6) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Thus, it seemed likely that the origin of the augmented P2X3 receptor activity of KI neurons might reside in a changed phosphorylation state of the intracellular protein domains.
Phosphorylation (phosphorylation) of P2X3 in neurons
7) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
NGF neutralization was associated with decreased threonine phosphorylation of P2X3 subunits, presumably accounting for their reduced responses and slower recovery.
Phosphorylation (phosphorylation) of P2X3
8) Confidence 0.62 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17670966 Disease Relevance 0.51 Pain Relevance 0.57
R192Q KI neurons lack constitutive serine phosphorylation of P2X3 receptors
Phosphorylation (phosphorylation) of P2X3 in neurons
9) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
However, we did observe decreased serine phosphorylation of P2X3 receptors as the molecular phenotype of CaV2.1-immunoreactive neurons in KI ganglia and in culture.
Phosphorylation (phosphorylation) of P2X3 in ganglia
10) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.14 Pain Relevance 0.11
The observation of decreased P2X3 receptor serine phosphorylation in KI neurons (see Fig. 5A) prompted us to consider the potential role of phosphatases contributing to this effect.
Phosphorylation (phosphorylation) of P2X3 in neurons
11) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.04
The phosphorylation state of P2X3 receptors is important to control ATP-mediated responses of nociceptive neurons
Phosphorylation (phosphorylation) of P2X3 in neurons associated with nociception
12) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.25 Pain Relevance 0.22
The inverse correlation between P2X3 serine phosphorylation and P2X3 activity (i.e., reduced serine phosphorylation associated with enhanced P2X3 receptor function) suggests that P2X3 serine dephosphorylation could be an important molecular contributor to receptor operation, particularly in view of the fact that Cdk5 (a kinase associated with negative P2X3 receptor regulating function [26]) was less associated with P2X3 receptors in neuronal membranes of KI neurons.
Phosphorylation (phosphorylation) of P2X3 in neuronal
13) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.06 Pain Relevance 0.06
The inverse correlation between P2X3 serine phosphorylation and P2X3 activity (i.e., reduced serine phosphorylation associated with enhanced P2X3 receptor function) suggests that P2X3 serine dephosphorylation could be an important molecular contributor to receptor operation, particularly in view of the fact that Cdk5 (a kinase associated with negative P2X3 receptor regulating function [26]) was less associated with P2X3 receptors in neuronal membranes of KI neurons.
Phosphorylation (phosphorylation) of P2X3 in neuronal
14) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.06 Pain Relevance 0.06
This treatment reversed the KI phenotype by decreasing the P2X3 receptor current (44 ± 5%, n = 20, p = 0.03; Fig. 6C) and in KI increased P2X3 receptor serine phosphorylation (134 ± 16%, n = 4, p = 0.03; Fig. 6D).
Phosphorylation (phosphorylation) of P2X3
15) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.03
Although no significant difference in membrane expression of knockin receptors was found, serine phosphorylation of knockin P2X3 receptors was constitutively decreased and restored by KN-93.
Phosphorylation (phosphorylation) of P2X3
16) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.54 Pain Relevance 0.39
The change in P2X3 receptor serine phosphorylation of KI neurons was linked to high CaMKII activity because pre-application of the selective CaMKII inhibitor KN-93 (5 ?
Phosphorylation (phosphorylation) of P2X3 in neurons
17) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
We have recently observed P2X3 receptor serine phosphorylation by Cdk5 to be a powerful negative regulator of receptor function [26].
Phosphorylation (phosphorylation) of P2X3
18) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
These results suggest that R192Q mutation in CaV2.1 channels conferred to KI trigeminal neurons a molecular phenotype with constitutively depressed serine phosphorylation of P2X3 receptors, together with upregulation of P2X3 receptor-mediated currents.
Phosphorylation (phosphorylation) of P2X3 in neurons
19) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Hence, we tested calcineurin involvement in P2X3 receptor phosphorylation state and function by incubating trigeminal neurons with the calcineurin inhibitor FK-506 (5 ?
Phosphorylation (phosphorylation) of P2X3 in neurons
20) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.04

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