INT145650

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 8.87
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLA2G6) cytoplasm (PLA2G6)
Anatomy Link Frequency
paneth cells 2
lumen 1
epithelial cells 1
urothelial cells 1
PLA2G6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 508 97.60 Very High Very High Very High
Calcium channel 17 95.16 Very High Very High Very High
cytokine 117 91.00 High High
Pain 15 78.16 Quite High
cINOD 69 73.68 Quite High
rheumatoid arthritis 17 65.36 Quite High
Inflammatory stimuli 15 56.20 Quite High
Inflammatory response 49 55.08 Quite High
agonist 4 29.76 Quite Low
antagonist 4 18.16 Low Low
Disease Link Frequency Relevance Heat
Cancer 65 100.00 Very High Very High Very High
Hypoxia 6 99.32 Very High Very High Very High
Carcinoma 12 99.16 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 102 99.06 Very High Very High Very High
Endotoxemia 3 98.96 Very High Very High Very High
Injury 46 98.28 Very High Very High Very High
INFLAMMATION 597 97.60 Very High Very High Very High
Disease 70 97.08 Very High Very High Very High
Otitis Media With Effusion 92 95.48 Very High Very High Very High
Otitis Media 134 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of the newly developed 2-oxoamides as well as those previously described have now been tested with the human Group V secreted PLA2 (GV sPLA2) and the human Group VIA calcium-independent PLA2 (GVIA iPLA2).
Localization (secreted) of PLA2
1) Confidence 0.76 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.18
The in vitro work confirms the evidence that PAR activation leads to iPLA2-mediated prostaglandin release in human urothelial carcinoma cell line RT4 [30], human bladder microvascular endothelial [59,60], and normal urothelial cells [61].
Localization (release) of iPLA2 in urothelial cells associated with carcinoma
2) Confidence 0.68 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.64 Pain Relevance 0.13
All of the newly developed 2-oxoamides as well as those previously described have now been tested with the human Group V secreted PLA2 (GV sPLA2) and the human Group VIA calcium-independent PLA2 (GVIA iPLA2).
Localization (secreted) of PLA2
3) Confidence 0.67 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.19
All of the newly developed 2-oxoamides as well as those previously described have now been tested with the human Group V secreted PLA2 (GV sPLA2) and the human Group VIA calcium-independent PLA2 (GVIA iPLA2).
Localization (secreted) of iPLA2
4) Confidence 0.67 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.19
The membrane localization of immunoreactive iPLA2 could be verified after subcellular fractionation, Triton X-100 treatment and western blotting (Figure 6B, [36]).
Localization (localization) of iPLA2
5) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.09
Phospholipases are mainly classified into three large groups: secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and calcium-independent PLA2 (iPLA2).
Localization (secretory) of PLA2
6) Confidence 0.42 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.80 Pain Relevance 0.32
Phospholipases are mainly classified into three large groups: secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and calcium-independent PLA2 (iPLA2).
Localization (secretory) of PLA2
7) Confidence 0.42 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.79 Pain Relevance 0.32
Phospholipases are mainly classified into three large groups: secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and calcium-independent PLA2 (iPLA2).
Localization (secretory) of PLA2
8) Confidence 0.42 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.81 Pain Relevance 0.32
Based on the stimulation of AA release by known cancer chemopreventative agents, I have proposed that AA release by cells is associated with cancer chemoprevention [23-27], possibly, but not necessarily, by activating a secreted tumor suppressor phospholipase A2 (PLA2) [28,29].
Localization (secreted) of PLA2 associated with cancer
9) Confidence 0.27 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 1.50 Pain Relevance 0
The secreted form of PLA2-II, responsible for the extracellular production of PAF, is expressed by many cell types including intestinal paneth cells and its release is triggered by hypoxia, endotoxemia, and trauma among other stimuli.
Localization (secreted) of PLA2 in paneth cells associated with endotoxemia, hypoxia and injury
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.17 Pain Relevance 0.07
The secreted form of PLA2-II, responsible for the extracellular production of PAF, is expressed by many cell types including intestinal paneth cells and its release is triggered by hypoxia, endotoxemia, and trauma among other stimuli.
Localization (release) of PLA2 in paneth cells associated with endotoxemia, hypoxia and injury
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.21 Pain Relevance 0.07
Indeed, several studies have shown that in this rodent model of NEC PAF levels as well as PAF-synthesizing enzyme PLA2 are increased in tissue homogenates and are secreted into the lumen [10].
Localization (secreted) of PLA2 in lumen associated with neonatal necrotizing enterocolitis
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.34 Pain Relevance 0
Although this effect is likely to be mediated via the inhibition of secretory rather than cytoplasmic PLA2, it outlines the importance of cPLA activity in intestinal inflammation in general.
Localization (secretory) of PLA2 associated with inflammation
13) Confidence 0.15 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.62 Pain Relevance 0.09
PLA2, exogenously administrated, increased mucous glycoprotein secretion in cultured chinchilla middle ear epithelial cells (238).
Localization (secretion) of PLA2 in epithelial cells
14) Confidence 0.12 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.91 Pain Relevance 0.05
The cPLA2 is one member of a larger family of enzymes organized into 11 groups (I-XI) that also include various secreted forms of PLA2 [4].
Localization (secreted) of PLA2
15) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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