INT145654

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.81
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Anatomy Link Frequency
neuronal 1
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 1 99.00 Very High Very High Very High
substance P 3 97.88 Very High Very High Very High
projection neuron 2 95.92 Very High Very High Very High
GABAergic 1 95.16 Very High Very High Very High
gABA 2 92.28 High High
Cannabinoid receptor 1 90.68 High High
Paracetamol 6 87.44 High High
agonist 3 86.12 High High
Cannabinoid 3 77.80 Quite High
adenocard 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 11 100.00 Very High Very High Very High
Toxicity 4 100.00 Very High Very High Very High
Alzheimer's Dementia 1 99.38 Very High Very High Very High
Cv General 4 Under Development 1 99.00 Very High Very High Very High
Infection 5 98.76 Very High Very High Very High
Aging 1 97.92 Very High Very High Very High
Stress 18 97.80 Very High Very High Very High
Epilepsy 1 89.44 High High
Ataxia 1 88.32 High High
Supranuclear Palsy 1 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, infection of AdSOD2-shRNA to Fisher 344 rats resulted in a significant decrease of SOD2 mRNA, protein expression, and SOD2 enzyme activity to 28%, 35%, and 39%, respectively, 7 days after infection.
Negative_regulation (decrease) of SOD2 associated with infection
1) Confidence 0.59 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.22
In this study, infection of AdSOD2-shRNA to Fisher 344 rats resulted in a significant decrease of SOD2 mRNA, protein expression, and SOD2 enzyme activity to 28%, 35%, and 39%, respectively, 7 days after infection.
Negative_regulation (decrease) of SOD2 associated with infection
2) Confidence 0.43 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.23
We also found reductions in mRNA levels for superoxide dismutase-1 (SOD-1) and -2 (SOD-2), which indicated that 3NP reduced the endogenous antioxidant defences.
Negative_regulation (reductions) of SOD-2
3) Confidence 0.22 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.74
In addition, aconitase inactivation has been observed in various animal and cell models of neuronal disorders and oxidative stress [32], [33] including excitotoxicity [17], cerebral ischemia [34], beta-amyloid toxicity [35], oxygen-glucose deprivation [30], MPTP toxicity [16], Sod2 and DJ1 mutant mice [18], [36], [37] as well as in aging [38], [39].
Negative_regulation (deprivation) of Sod2 in neuronal associated with parkinson's disease, stress, toxicity, aging, cv general 4 under development, ischemia and alzheimer's dementia
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.63 Pain Relevance 0.14

General Comments

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