INT145655

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
endothelial cells 1
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 97.12 Very High Very High Very High
projection neuron 4 95.16 Very High Very High Very High
GABAergic 2 94.40 High High
gABA 4 91.52 High High
Cannabinoid receptor 2 89.92 High High
allodynia 21 88.12 High High
agonist 21 85.36 High High
B1 receptor 91 82.32 Quite High
Cannabinoid 6 77.04 Quite High
adenocard 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 33 94.16 High High
Insulin Resistance 13 89.04 High High
Neuropathic Pain 26 88.12 High High
Pressure And Volume Under Development 19 87.68 High High
Frailty 2 75.00 Quite High
Diabetes Mellitus 17 74.24 Quite High
Hypertension 4 5.52 Low Low
Pain 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Diabetes Complications 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found reductions in mRNA levels for superoxide dismutase-1 (SOD-1) and -2 (SOD-2), which indicated that 3NP reduced the endogenous antioxidant defences.
Transcription (levels) of dismutase-1
1) Confidence 0.42 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.71
We also found reductions in mRNA levels for superoxide dismutase-1 (SOD-1) and -2 (SOD-2), which indicated that 3NP reduced the endogenous antioxidant defences.
Transcription (levels) of SOD-1
2) Confidence 0.42 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.71
Exposure of human endothelial cells to 20 mM glucose for 1–2 weeks increased mRNA expression of CuZnSOD and MnSOD [48].
Transcription (expression) of CuZnSOD in endothelial cells
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.77 Pain Relevance 0.43

General Comments

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