INT145657

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
gABA 4 99.62 Very High Very High Very High
projection neuron 4 95.16 Very High Very High Very High
GABAergic 2 94.40 High High
Cannabinoid receptor 2 89.92 High High
Substantia nigra 2 86.72 High High
Paracetamol 3 86.64 High High
agonist 6 85.36 High High
antagonist 6 80.72 Quite High
Cannabinoid 6 77.04 Quite High
Disease Link Frequency Relevance Heat
Infection 2 98.52 Very High Very High Very High
Stress 3 76.52 Quite High
Hepatotoxicity 3 75.00 Quite High
Frailty 2 75.00 Quite High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, infection of AdSOD2-shRNA to Fisher 344 rats resulted in a significant decrease of SOD2 mRNA, protein expression, and SOD2 enzyme activity to 28%, 35%, and 39%, respectively, 7 days after infection.
Transcription (expression) of SOD2 associated with infection
1) Confidence 0.72 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.23
We also found reductions in mRNA levels for superoxide dismutase-1 (SOD-1) and -2 (SOD-2), which indicated that 3NP reduced the endogenous antioxidant defences.
Transcription (levels) of SOD-2
2) Confidence 0.37 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.74
The administration of CBD, but not ACEA or HU-308, completely reversed 3NP-induced reductions in GABA contents and mRNA levels for SP, NSE and SOD-2, and partially attenuated those found in SOD-1 and PENK.
Transcription (levels) of SOD-2 associated with gaba and substance p
3) Confidence 0.12 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.85

General Comments

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