INT145661

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.73
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA) signal transducer activity (Ptger2) signal transduction (Ptger2)
extracellular space (VEGFA) extracellular region (VEGFA) growth (VEGFA)
Anatomy Link Frequency
cochlea 2
fibroblasts 2
inner ear 2
PGE2 2
Ptger2 (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 111 100.00 Very High Very High Very High
COX-2 inhibitor 10 95.20 Very High Very High Very High
antagonist 3 95.16 Very High Very High Very High
Central nervous system 4 84.56 Quite High
anesthesia 8 66.00 Quite High
palliative 1 26.60 Quite Low
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
Versed 6 19.52 Low Low
Inflammation 1 18.56 Low Low
Disease Link Frequency Relevance Heat
Cancer 146 99.48 Very High Very High Very High
Ganglion Cysts 34 98.24 Very High Very High Very High
Targeted Disruption 5 98.20 Very High Very High Very High
Hypoxia 5 96.64 Very High Very High Very High
Ulcers 1 92.44 High High
Injury 14 86.16 High High
Peptic Ulcer 5 85.44 High High
Breast Cancer 43 80.08 Quite High
Prostate Cancer 1 78.08 Quite High
Wound Healing 1 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings provide new insights into the mechanisms underlying the regulation of VEGF expression in the cochlea, which is mediated by EP2 and EP4.
EP2 Positive_regulation (mediated) of Gene_expression (expression) of VEGF in cochlea
1) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.36 Pain Relevance 0.04
The present study demonstrated that local EP2 and EP4 agonist treatment induces VEGF synthesis in the inner ear, especially in the spiral ganglion neurons.
EP2 Positive_regulation (induces) of Gene_expression (synthesis) of VEGF in inner ear associated with ganglion cysts and agonist
2) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.32 Pain Relevance 0.23
The expression of VEGF in primary rat gastric fibroblasts was increased by PGE2 or AE1-329 (EP4 agonist), and these responses were both attenuated by coadministration of CJ-42794.
PGE2 Positive_regulation (increased) of Gene_expression (expression) of VEGF in fibroblasts associated with agonist
3) Confidence 0.04 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17673547 Disease Relevance 0.51 Pain Relevance 0.25
It was recently reported that COX-2 induced PGE2 stimulated the expression of angiogenic regulatory genes, including VEGF, in mammary tumor cells isolated from COX-2 transgenic mice, and that treatment with indomethacin (a nonspecific COX inhibitor) suppressed the expression of these genes in vitro [36].
PGE2 Positive_regulation (stimulated) of Gene_expression (expression) of VEGF associated with targeted disruption and cancer
4) Confidence 0.02 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.56 Pain Relevance 0.08
PGE2 stimulates the expression of VEGF, the key regulator of angiogenesis [6,30,31].
PGE2 Positive_regulation (stimulates) of Gene_expression (expression) of VEGF in PGE2
5) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 0.98 Pain Relevance 0

General Comments

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