INT145681

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 3.41
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
C8-B4 9
spinal 1
cerebellum 1
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 350 99.98 Very High Very High Very High
chemokine 10 99.64 Very High Very High Very High
fluoxetine 30 99.54 Very High Very High Very High
Desipramine 30 99.30 Very High Very High Very High
Endep 160 99.04 Very High Very High Very High
antagonist 61 98.92 Very High Very High Very High
Neuropathic pain 213 98.32 Very High Very High Very High
Spinal cord 44 98.28 Very High Very High Very High
Stimulus evoked pain 6 98.12 Very High Very High Very High
Pain 32 88.92 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 64 99.92 Very High Very High Very High
Neuropathic Pain 249 98.32 Very High Very High Very High
Spinal Cord Injury 10 98.28 Very High Very High Very High
Hypersensitivity 8 98.12 Very High Very High Very High
Pain 48 97.44 Very High Very High Very High
Disease 3 93.76 High High
Anaplastic Astrocytoma 10 92.28 High High
INFLAMMATION 22 87.76 High High
Neurodegenerative Disease 2 41.04 Quite Low
Injury 12 11.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation.
Regulation (regulation) of P2X4
1) Confidence 0.61 Published 2007 Journal Neuropharmacology Section Title Doc Link 17675190 Disease Relevance 0.36 Pain Relevance 0.21
We next determined whether amitriptyline, desipramine, fluoxetine, and paroxetine could affect P2X4 receptor up-regulation in activated C8-B4 cells.
Regulation (affect) of P2X4 in C8-B4 associated with desipramine, endep and fluoxetine
2) Confidence 0.53 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.67
In accord, P2X4 colocalized with the lysosomal marker LAMP1, confirming that native P2X4 receptors within resting C8-B4 cells are targeted to this intracellular organelle.
Regulation (targeted) of P2X4 in C8-B4
3) Confidence 0.53 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Fourth, our studies provide the basis to determine if up-regulation of microglial P2X4 receptors contributes to the development and physiology of the cerebellum, where microglia are known to play important roles (Marín-Teva et al., 2004; Bessis et al., 2007).


Regulation (regulation) of P2X4 in cerebellum
4) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
This is the opposite of our data with C8-B4 cells, revealing the diversity of mechanisms that may regulate P2X4 receptors in a cell- and context-specific manner.


Spec (may) Regulation (regulate) of P2X4 in C8-B4
5) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Seventh, several antidepressants at 500-nM concentrations impair lysosome function, which secondarily blocks cell surface up-regulation of P2X4 receptors in activated C8-B4 cells.
Regulation (regulation) of P2X4 in C8-B4 associated with antidepressant
6) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.08 Pain Relevance 0.27
Given that microglial up-regulation of P2X4 receptors has emerged as an important step in the initiation of neuropathic pain (Trang et al., 2006; Inoue, 2008), we experimentally determined whether antidepressants affected native C8-B4 cell P2X4 receptors directly or blocked their up-regulation.
Regulation (regulation) of P2X4 in C8-B4 associated with antidepressant and neuropathic pain
7) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.44 Pain Relevance 0.63
Fourth, the up-regulated P2X4 receptors in activated C8-B4 cells are from a preexisting lysosomal pool that is trafficked to the plasma membrane.
Regulation (regulated) of P2X4 in C8-B4
8) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.28
Fifth, C8-B4 cell activation results in up-regulation of P2X4 transcripts, but this is not associated with any measurable increase in total P2X4 protein levels.
Regulation (regulation) of P2X4 in C8-B4
9) Confidence 0.39 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.28
We now know that many receptors such as P2X4, CX3CR1, and CCR2 are specifically expressed or up regulated in spinal microglia after nerve injury or spinal cord injury, which is essential for neuropathic pain development and maintenance.
Regulation (regulated) of P2X4 associated with nervous system injury, neuropathic pain and spinal cord
10) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.83 Pain Relevance 0.76
We determined if several commonly used antidepressants (paroxetine, fluoxetine, desipramine, and amitriptyline; see Figs. 11–14 for experimental details) blocked P2X4 receptor responses in activated C8-B4 cells.
Regulation (responses) of P2X4 in C8-B4 associated with desipramine, antidepressant, endep and fluoxetine
11) Confidence 0.23 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.09 Pain Relevance 0.54
Given that microglial up-regulation of P2X4 receptors has emerged as an important step in the initiation of neuropathic pain (Trang et al., 2006; Inoue, 2008), we experimentally determined whether antidepressants affected native C8-B4 cell P2X4 receptors directly or blocked their up-regulation.
Spec (whether) Regulation (affected) of P2X4 in C8-B4 associated with antidepressant and neuropathic pain
12) Confidence 0.23 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.43 Pain Relevance 0.64
Fortunately, nerve injury up regulates the ATP receptor P2X4 and the chemokine receptor CX3CR1 specifically in spinal microglia, and blocking these receptors results in decreased neuropathic pain [24-26].
Regulation (regulates) of P2X4 in spinal associated with chemokine, nervous system injury and neuropathic pain
13) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.18 Pain Relevance 0.79

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