INT145682

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx4, P2rx7) plasma membrane (P2rx4, P2rx7) cell morphogenesis (P2rx7)
mitochondrion organization (P2rx7) protein complex (P2rx7) transmembrane transport (P2rx7)
Anatomy Link Frequency
microglial cells 1
P2rx4 (Mus musculus)
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 98.42 Very High Very High Very High
antidepressant 35 97.56 Very High Very High Very High
antagonist 7 95.08 Very High Very High Very High
Neuropathic pain 10 85.96 High High
Spinal cord 1 36.04 Quite Low
Dorsal horn 1 35.28 Quite Low
Eae 1 26.68 Quite Low
allodynia 1 24.80 Low Low
Endep 16 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.42 Very High Very High Very High
Neuropathic Pain 12 85.96 High High
Disease 1 85.12 High High
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated changes in surface P2X receptors in BV-2 murine microglial cells following their activation by pro-inflammatory bacterial lipopolysaccharides (LPS). mRNA analysis using RT-PCR confirmed the presence of P2X4 and P2X7 as the main P2X subunits.
P2X4 Binding (presence) of P2X7 in microglial cells associated with inflammation
1) Confidence 0.25 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17675190 Disease Relevance 0.36 Pain Relevance 0.22
Additionally, P2X4 receptors form functional heteromers with P2X6 subunits (LĂȘ et al., 1998a; Ormond et al., 2006) and undergo interactions with P2X7 receptors (Guo et al., 2007; Nicke, 2008; Alqallaf et al., 2009; Boumechache et al., 2009; Casas-Pruneda et al., 2009; Murrell-Lagnado, 2009).
P2X4 Binding (interactions) of P2X7
2) Confidence 0.12 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.10

General Comments

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