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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.52
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
muscles 2
body 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 2 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
narcan 5 99.98 Very High Very High Very High
Opioid 1 98.06 Very High Very High Very High
Endogenous opioid 1 46.08 Quite Low
tolerance 11 35.52 Quite Low
Inflammatory response 3 20.80 Low Low
cytokine 1 15.20 Low Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 25 99.76 Very High Very High Very High
Diabetes Mellitus 140 98.64 Very High Very High Very High
Obesity 26 97.36 Very High Very High Very High
Polycystic Ovary Syndrome 9 97.12 Very High Very High Very High
Shock 1 96.20 Very High Very High Very High
Injury 96 94.42 High High
Hyperinsulinism 1 91.88 High High
Critical Illness 8 87.60 High High
Cancer 77 85.08 High High
Impaired Glucose Tolerance 9 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that the upregulation of the insulin signaling pathway at the gene expression level observed in the relatives could be an effective compensation for otherwise reduced insulin signaling activity.
Positive_regulation (compensation) of Negative_regulation (reduced) of insulin
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.89 Pain Relevance 0
Early in the disease process, a small insulin deficiency or slightly raised blood sugar levels would increase TXNIP expression in muscles and suppress glucose uptake by these cells.
Positive_regulation (increase) of Negative_regulation (deficiency) of small insulin in muscles associated with disease
2) Confidence 0.34 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.58 Pain Relevance 0
Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects.
Positive_regulation (induced) of Negative_regulation (blockade) of insulin associated with obesity, narcan, polycystic ovary syndrome, opiate and opioid
3) Confidence 0.10 Published 1990 Journal Fertil. Steril. Section Abstract Doc Link 1697813 Disease Relevance 1.13 Pain Relevance 0.32
Following acute injury, the body undergoes 3 phases of recovery in terms of metabolic activity: the early shock or ebb phase, followed by the catabolic or flow phase, culminating in the anabolic phase.110 Patients in the initial poststress period have an altered chemical environment characterized by increased levels of glucocorticoids, glucagon, and catecholamines, along with a decreased level of insulin.
Positive_regulation (increased) of Negative_regulation (decreased) of insulin in body associated with catecholamine, shock and injury
4) Confidence 0.03 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.92 Pain Relevance 0.05

General Comments

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