INT145693

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 2.54
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc10a2) nucleus (Slc10a2)
Anatomy Link Frequency
bile 7
enterocytes 2
Slc10a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 448 100.00 Very High Very High Very High
fibrosis 240 91.96 High High
spastic colon 12 90.00 High High
sodium channel 48 67.44 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 72 95.62 Very High Very High Very High
Cystic Fibrosis 240 91.96 High High
Diarrhoea 4 90.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 90.00 High High
Functional Bowel Disorder 4 85.96 High High
Lower Respiratory Tract Infection 8 85.00 Quite High
Liver Disease 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Dislocations 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, increased ASBT expression was observed in infected animals.
Gene_expression (expression) of ASBT
1) Confidence 0.78 Published 2008 Journal Gut Section Body Doc Link 17675326 Disease Relevance 0 Pain Relevance 0
ASBT protein expression was determined by Western blot analysis and immunohistochemistry.
Gene_expression (expression) of ASBT
2) Confidence 0.78 Published 2008 Journal Gut Section Body Doc Link 17675326 Disease Relevance 0 Pain Relevance 0
The results of this study open up further avenues of investigation with respect to the role of the mucus layer in causing a secondary up-regulation of IBAT expression and function.
Gene_expression (expression) of IBAT
3) Confidence 0.77 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.35 Pain Relevance 0.26
This may result in an altered programming of ileal stem cells and transit cells that give rise to absorptive enterocytes over-expressing IBAT protein.
Gene_expression (-) of IBAT in enterocytes
4) Confidence 0.77 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.17 Pain Relevance 0.57
The correlation between zygosity and level of IBAT protein expression suggests a close relationship between the function of the CFTR chloride channel and the sodium-dependent ileal bile acid transporter.
Gene_expression (expression) of IBAT in bile associated with bile
5) Confidence 0.77 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.15 Pain Relevance 0.19
In summary, in the widely studied cftr knockout mouse model (which clearly demonstrates intestinal pathology), the apical sodium dependent ileal bile acid transporter is expressed and functions at higher levels than in wild-type animals, with intermediate levels of IBAT expression and function in heterozygous cftr (+/-) mice.
Gene_expression (expression) of IBAT in bile associated with targeted disruption and bile
6) Confidence 0.60 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.40 Pain Relevance 0.31
This may result in an altered programming of ileal stem cells and transit cells that give rise to absorptive enterocytes over-expressing IBAT protein.
Gene_expression (expressing) of IBAT in enterocytes
7) Confidence 0.60 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.17 Pain Relevance 0.57
This study examines the expression of the ileal bile acid transporter protein (IBAT) and rates of diffusional (sodium independent) and active (sodium dependent) uptake of the radiolabeled bile acid taurocholate in mice with targeted disruption of the cftr gene.


Spec (examines) Gene_expression (expression) of IBAT in bile associated with targeted disruption and bile
8) Confidence 0.60 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.26 Pain Relevance 0.32
Changes in the protein expression of apical sodium-dependent bile acid transporter (ASBT) were also measured.
Gene_expression (expression) of sodium-dependent bile acid transporter in bile associated with bile
9) Confidence 0.53 Published 2008 Journal Gut Section Abstract Doc Link 17675326 Disease Relevance 0.18 Pain Relevance 0.53
Changes in the protein expression of apical sodium-dependent bile acid transporter (ASBT) were also measured.
Gene_expression (expression) of ASBT in bile associated with bile
10) Confidence 0.53 Published 2008 Journal Gut Section Abstract Doc Link 17675326 Disease Relevance 0.18 Pain Relevance 0.53
In contrast, cftr (-/-) mice may experience bile acid malabsorption even though their ileal mucosal cells express four-fold more IBAT transporters than normal cells.
Gene_expression (express) of IBAT in bile associated with bile
11) Confidence 0.52 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.08 Pain Relevance 0.53
This study examines the expression of the ileal bile acid transporter protein (IBAT) and rates of diffusional (sodium independent) and active (sodium dependent) uptake of the radiolabeled bile acid taurocholate in mice with targeted disruption of the cftr gene.


Gene_expression (expression) of ileal bile acid transporter protein in bile associated with targeted disruption and bile
12) Confidence 0.52 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.26 Pain Relevance 0.32

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