INT145695

Context Info Confidence 0.62 First Reported 2004 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 26 Total Number 26 Disease Relevance 14.67 Pain Relevance 9.83

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8) nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)

Anatomy Link Frequency macrophages 2 spinal 1 Acb 1 CPu 1 FrA 1 Mapk8 (Mus musculus)

Pain Link Frequency Relevance Heat addiction 15 100.00 cytokine 89 99.52 Neuropathic pain 12 99.18 Nucleus accumbens 18 98.88 long-term potentiation 312 98.66 Eae 12 98.42 Morphine 33 97.16 withdrawal 46 96.20 Inflammatory response 11 95.60 Spinal cord 140 95.20

Disease Link Frequency Relevance Heat Reprotox - General 1 81 99.80 Neuropathic Pain 19 99.18 Stress 244 98.98 Apoptosis 172 98.60 Lung Injury 62 98.44 Cancer 275 98.16 Morphine Dependence 9 97.16 Metastasis 24 96.64 Sprains And Strains 237 96.44 INFLAMMATION 165 95.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These observations suggest that the steady state levels of JNK1 are controlled by factors other than transcription.

Regulation (controlled) of JNK1

1) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.38 Pain Relevance 0.30

A number of proteins negatively regulate JNK.

Regulation (regulate) of JNK

2) Confidence 0.49 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.67 Pain Relevance 0

The polymorphic nature of the mitogen activated protein kinase 8 (Mapk8) gene

Regulation (nature) of mitogen activated protein kinase 8

3) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.48 Pain Relevance 0.33

Using spinal nerve ligation to create a model of neuropathic pain, Zhuang et al. demonstrated that the up-regulation of JNK1 occurred primarily in spinal astrocytes, and that the spinal administration of a selective JNK1 inhibitor blocked the resulting hypersensitivity [21].

Regulation (regulation) of JNK1 in spinal associated with eae, hypersensitivity and neuropathic pain

4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.83 Pain Relevance 0.42

The polymorphic nature of the mitogen activated protein kinase 8 (Mapk8) gene

Regulation (nature) of Mapk8

5) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.48 Pain Relevance 0.33

This elevated expression was abrogated by JNK1 mutation and the JNK inhibitor, indicating the dependence of MUC5AC expression on JNK activity.

Regulation (dependence) of JNK associated with addiction

6) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.58 Pain Relevance 0.08

Cytokines administration did not alter ERK1/2 and JNK1/2 phosphorylation.

Neg (not) Regulation (alter) of JNK1 associated with cytokine

7) Confidence 0.44 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17678631 Disease Relevance 0.24 Pain Relevance 0.67

B, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion.

Regulation (regulators) of JNK associated with cancer and cytokine

8) Confidence 0.42 Published 2010 Journal Gastroenterology Research and Practice Section Abstract Doc Link PMC2995932 Disease Relevance 0.71 Pain Relevance 0.13

B and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. 3.

Regulation (regulators) of JNK associated with cancer and cytokine

9) Confidence 0.42 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.62 Pain Relevance 0.21

Then we tested the effects of JNK or p38 inhibitor on the induction of cingulate LTP, because the MAPK signaling pathways include extracellular signal-regulated (ERK), c-Jun N-terminal kinase (JNK), p38 and ERK5 [17].

Regulation (regulated) of c-Jun N-terminal kinase associated with long-term potentiation

10) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.29

Then we tested the effects of JNK or p38 inhibitor on the induction of cingulate LTP, because the MAPK signaling pathways include extracellular signal-regulated (ERK), c-Jun N-terminal kinase (JNK), p38 and ERK5 [17].

Regulation (regulated) of JNK associated with long-term potentiation

11) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.29

Then we tested the effects of JNK or p38 inhibitor on the induction of cingulate LTP, because the MAPK signaling pathways include extracellular signal-regulated (ERK), c-Jun N-terminal kinase (JNK), p38 and ERK5 [17].

Regulation (effects) of JNK associated with long-term potentiation

12) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.30

have been shown to regulate JNK and p38 MAPK signaling to promote apoptosis [53].

Regulation (regulate) of JNK associated with apoptosis

13) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.91 Pain Relevance 0.12

There is also participation in the transcriptional regulation of growth factors such as EGF through JNK activation [61].

Regulation (regulation) of JNK

14) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.43 Pain Relevance 0

However, the activities of other protein kinases in the MAPK pathway, including p38 and JNK, showed no changes in FrA, Acb and CPu of the mice during the chronic morphine dependence and withdrawal phases.

Regulation (activities) of JNK in Acb associated with addiction, nucleus accumbens, withdrawal and morphine

15) Confidence 0.24 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 19922770 Disease Relevance 0.79 Pain Relevance 1.77

This study suggests that JNK is a potential target for prostate cancer growth.

Regulation (target) of JNK associated with reprotox - general 1

16) Confidence 0.21 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.65 Pain Relevance 0.06

Protandim diet alone did not affect either Jun D/Fra-1 or pJNK level significantly.

Neg (not) Regulation (affect) of pJNK

17) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.60 Pain Relevance 0.13

We found that LPS significantly increased the concentrations of TLR-4, NF-kappaB and MAPKs, including extracellular regulated kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAPK, in activated macrophages.

Regulation (concentrations) of c-jun N-terminal kinase in macrophages

18) Confidence 0.20 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.13 Pain Relevance 0.39

We found that LPS significantly increased the concentrations of TLR-4, NF-kappaB and MAPKs, including extracellular regulated kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAPK, in activated macrophages.

Regulation (concentrations) of JNK in macrophages

19) Confidence 0.20 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.13 Pain Relevance 0.39

There are several reports indicating that factors other than those within the IGF-1/insulin/PI3K/Akt signaling pathway are involved in the regulation of FOXO activity, including but not limited to serum and glucocorticoid-inducible kinase (SGK), jun-N-terminal kinase (JNK), and ?

Regulation (regulation) of jun-N-terminal kinase

20) Confidence 0.16 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.82 Pain Relevance 0

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