INT14570

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.97
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
skeletal muscle 2
epithelium 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 5 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
dexamethasone 6 99.20 Very High Very High Very High
Opioid 1 98.44 Very High Very High Very High
Clonidine 1 87.80 High High
ischemia 4 50.00 Quite Low
agonist 4 49.04 Quite Low
Inflammation 17 48.48 Quite Low
Endogenous opioid 1 46.08 Quite Low
cytokine 5 38.24 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 45 98.94 Very High Very High Very High
Hypoxia 31 97.80 Very High Very High Very High
Obesity 32 97.36 Very High Very High Very High
Polycystic Ovary Syndrome 67 97.12 Very High Very High Very High
Pulmonary Disease 16 95.08 Very High Very High Very High
Diabetes Mellitus 236 93.52 High High
Hyperinsulinism 14 92.64 High High
Bronchitis 4 89.60 High High
Syndrome 1 84.72 Quite High
Cardiovascular Disease 17 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were no acute effects on pulmonary function in response to insulin inhalation.53
Neg (no) Regulation (effects) of Positive_regulation (response) of insulin
1) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.94 Pain Relevance 0
Both lung volumes and diffusion capacity change as a function of age.54 These changes can modulate both delivery of inhaled insulin to the distal airways, as well as absorption of the insulin across the alveolar epithelium.
Regulation (modulate) of Positive_regulation (absorption) of insulin in epithelium
2) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.75 Pain Relevance 0
Additional studies will be needed to assess the effect of an improvement in insulin sensitivity to improve the myocardial perfusion as well to investigate cost effectiveness of using SPECT in prediabetics.
Regulation (effect) of Positive_regulation (improvement) of insulin
3) Confidence 0.39 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC2982198 Disease Relevance 0.86 Pain Relevance 0
It is unlikely that this relatively small increase in insulin should be responsible for the observed changes in skeletal muscle protein turnover [30].
Regulation (responsible) of Positive_regulation (increase) of insulin in skeletal muscle
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004931 Disease Relevance 0.43 Pain Relevance 0
In a prospective study [20], metformin acutely improved insulin resistance indexes and restored ovarian morphology, whereas no effect of the metformin-induced improved insulin-sensitivity and AMH levels was observed.
Neg (no) Regulation (effect) of Neg (no) Positive_regulation (induced) of insulin associated with insulin resistance
5) Confidence 0.21 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.49 Pain Relevance 0
Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects.
Regulation (effect) of Positive_regulation (induced) of insulin associated with obesity, narcan, polycystic ovary syndrome, opiate and opioid
6) Confidence 0.06 Published 1990 Journal Fertil. Steril. Section Abstract Doc Link 1697813 Disease Relevance 1.14 Pain Relevance 0.32
A significant increase in insulin values was observed after dexamethasone administration (before: 120 +/- 10 micromol/l; after: 175 +/- 27 pmol/l; p<0.05), while glucose levels did not reach statistical significance (before: 4.6 +/- 0.3 mmol/l; after: 5.9 +/- 1.0 mmol/l).
Regulation (values) of Positive_regulation (increase) of insulin associated with dexamethasone
7) Confidence 0.05 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.08 Pain Relevance 0.30
Furthermore, the treatment had a significant effect on pancreatic insulin supply, as reflected by a more than three-fold increase of pancreatic insulin content in animals treated with the IKK?
Regulation (effect) of Positive_regulation (pancreatic) of insulin
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0.29 Pain Relevance 0

General Comments

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